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Table 5 Profiles associated with a negative outcome in our cohort

From: Mutational analysis of selected high-grade malignancies in a premenopausal gynecologic cancer population: a potential for targeted therapies?

Cancer Type

Location

Chemo

Mutation Profile (significant genes)

Mutation Loada

APCb

ABL2b

Epithelial

Ovary

Carbo/Taxol

ERBB3 only (1)

22

neg

neg

NE

Ovary

Plat/Etoposide

ALK, GPR124, KMT2D (1)

27

neg

neg

 

Endometrial

Carbo/Taxol

ROS1, ALK, ERBB3, GPR124, KMT2D, NTRK1 (1)

111

neg

neg

Sarcoma/Other

Ovary

Unknown

None

ROS1, EGFR (1)

ROS1, ERBB3, KMT2D, NTRK1 (1)

27

29

neg

neg

 

Endometrial

None

GPR124 (1)

21

neg

neg

  1. amutation load in our cohort based on the genes in our molecular profile; bneg indicates no mutation