From: Clinical significance of p27 Kip1 expression in advanced ovarian cancer
 | IHC | mRNA P27 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
P27 + ve | P27 -ve |  |  | Upregulation of P27 | Downregulation of P27 |  |  | |||||
N | % | N | % | t-test | P | N | % | N | % | t-test | P | |
Stage | ||||||||||||
 IIIAa | 8 | 80 | 2 | 20 | 2.4 | 0.04 | 8 | 80 | 2 | 20 | 2.372 | 0.042 |
 IIIBa | 10 | 83.3 | 2 | 16.7 | 3.09 | 0.01 | 10 | 83.3 | 2 | 16.7 | 3.093 | 0.01 |
 IIICa | 24 | 36.3 | 42 | 63.7 | 2.32 | 0.02 | 24 | 36.3 | 42 | 63.7 | 2.315 | 0.024 |
Grade | ||||||||||||
 Moderate + Well differentiated | 26 | 86.7 | 4 | 13.3 | 5.92 | <  0.001 | 26 | 86.7 | 4 | 13.3 | 5.92 | <  0.001 |
 Poorly differentiated | 16 | 27.6 | 42 | 72.4 | 3.82 | <  0.001 | 16 | 27.6 | 42 | 72.4 | 3.816 | <  0.001 |
Pathology | ||||||||||||
 Serous | 38 | 61.3 | 24 | 38.7 | 1.83 | 0.07 | 40 | 62.5 | 24 | 37.5 | 2.066 | 0.043 |
 Non- serous | 4 | 15.4 | 22 | 84.6 | 4.89 | < 0.001 | 2 | 8.3 | 22 | 91.7 | 7.405 | < 0.001 |
Ascites | ||||||||||||
 Absent | 24 | 85.7 | 4 | 14.3 | 5.92 | < 0.001 | 24 | 85.7 | 4 | 14.3 | 5.396 | < 0.001 |
 Present | 18 | 30 | 42 | 70 | 3.38 | 0.00 | 14 | 23.3 | 46 | 76.7 | 4.892 | < 0.001 |
Response | ||||||||||||
 CR, Microscopic disease, PRa | 40 | 87 | 6 | 13 | 7.46 | < 0.001 | 41 | 89.1 | 5 | 10.9 | 8.509 | < 0.001 |
 No response or progressive disease | 2 | 4.8 | 40 | 95.2 | 13.7 | < 0.001 | 1 | 3.4 | 41 | 97.6 | 17.43 | < 0.001 |
Residual Disease | ||||||||||||
 >  2 cm | 18 | 30 | 42 | 70 | 3.38 | 0.00 | 15 | 25 | 45 | 75 | 4.472 | < 0.001 |
 <  2 cm | 24 | 85.7 | 4 | 14.3 | 5.4 | < 0.001 | 21 | 75 | 7 | 25 | 3.055 | 0.005 |