|
Clinical features
|
Aberrant WWOX expression
|
|---|
|
Reduced or lost protein (56)b
|
Reduced or lost RNA (60)c
|
|---|
|
No. (%)
|
P. value
|
No. (%)
|
P value
|
|---|
|
Gender
|
|
Males (52)
|
40 (76.9)
| |
38 (73.1)
|
0.588
|
|
Females (28)
|
16 (57.1)
|
0.066
|
22 (78.6)
| |
|
Age (median)
|
|
< 21 years (40)
|
32 (80)
| |
30 (50)
|
1.0
|
|
≥ 21 years (40)
|
24 (60)
|
0.051
|
30 (50)
| |
|
Site
|
|
Femur (48)
|
34 (70.8)
| |
35 (72.9)
| |
|
Tibia (20)
|
12 (60)
|
0.371
|
15 (75)
|
0.571
|
|
Humerus (12)
|
10 (83.3)
| |
10 (83.3)
| |
|
Tumor Grade
|
|
2 (16)
|
9 (56.3)
| |
10 (62.5)
| |
|
3 (64)
|
47 (73.4)
|
0.180
|
50 (78.1)
|
0.197
|
|
pTNM Stage
|
|
I, II (44)
|
24 (54.5)
|
0.001
|
32 (72.7)
|
0.604
|
|
III, IV (36)
|
32 (88.9)
| |
28 (77.8)
| |
|
Metastasis
|
|
Present (20)
|
18 (90)
|
0.024a
|
20 (100)
|
0.003
|
|
Absent (60)
|
38 (63.3)
|
40 (66.7)
|
-
aSignificant $Borderline significance (using intensity score)
-
bNormal WWOX protein expression: 24 cNormal WWOX RNA expression: 20
