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Table 1 The relation between WWOX (protein and RNA) expressions and the clinicopathological features of the patients

From: RUNX2 and WWOX genes as molecular biomarkers and candidates for targeted therapy in Egyptian patients with primary conventional osteosarcoma

Clinical features Aberrant WWOX expression
Reduced or lost protein (56)b Reduced or lost RNA (60)c
No. (%) P. value No. (%) P value
Gender
 Males (52) 40 (76.9)   38 (73.1) 0.588
 Females (28) 16 (57.1) 0.066 22 (78.6)  
Age (median)
  < 21 years (40) 32 (80)   30 (50) 1.0
  ≥ 21 years (40) 24 (60) 0.051 30 (50)  
Site
 Femur (48) 34 (70.8)   35 (72.9)  
 Tibia (20) 12 (60) 0.371 15 (75) 0.571
 Humerus (12) 10 (83.3)   10 (83.3)  
Tumor Grade
 2 (16) 9 (56.3)   10 (62.5)  
 3 (64) 47 (73.4) 0.180 50 (78.1) 0.197
pTNM Stage
 I, II (44) 24 (54.5) 0.001 32 (72.7) 0.604
 III, IV (36) 32 (88.9)   28 (77.8)  
Metastasis
 Present (20) 18 (90) 0.024a 20 (100) 0.003
 Absent (60) 38 (63.3) 40 (66.7)
  1. aSignificant $Borderline significance (using intensity score)
  2. bNormal WWOX protein expression: 24 cNormal WWOX RNA expression: 20
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