Applied Cancer Research

Table 1 The relation between WWOX (protein and RNA) expressions and the clinicopathological features of the patients

From: RUNX2 and WWOX genes as molecular biomarkers and candidates for targeted therapy in Egyptian patients with primary conventional osteosarcoma

Clinical features	Aberrant WWOX expression
	Reduced or lost protein (56)^b		Reduced or lost RNA (60)^c
	No. (%)	P. value	No. (%)	P value
Gender
Males (52)	40 (76.9)		38 (73.1)	0.588
Females (28)	16 (57.1)	0.066	22 (78.6)
Age (median)
< 21 years (40)	32 (80)		30 (50)	1.0
≥ 21 years (40)	24 (60)	0.051	30 (50)
Site
Femur (48)	34 (70.8)		35 (72.9)
Tibia (20)	12 (60)	0.371	15 (75)	0.571
Humerus (12)	10 (83.3)		10 (83.3)
Tumor Grade
2 (16)	9 (56.3)		10 (62.5)
3 (64)	47 (73.4)	0.180	50 (78.1)	0.197
pTNM Stage
I, II (44)	24 (54.5)	0.001	32 (72.7)	0.604
III, IV (36)	32 (88.9)		28 (77.8)
Metastasis
Present (20)	18 (90)	0.024^a	20 (100)	0.003
Absent (60)	38 (63.3)	0.024^a	40 (66.7)	0.003

^aSignificant ^$Borderline significance (using intensity score)
^bNormal WWOX protein expression: 24 ^cNormal WWOX RNA expression: 20

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