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Table 2 The relation between RUNX2 (protein and RNA) expressions and the clinicopathological features of the patients

From: RUNX2 and WWOX genes as molecular biomarkers and candidates for targeted therapy in Egyptian patients with primary conventional osteosarcoma

Clinical features RUNX2 expression
RUNX2 protein expression (72/80) RUNX2 -RNA expression (60/80)
No. (%) P value No. (%) P value
Gender
 Males (52) 48 (92.3)   44 (84.6)  
 Females (28) 24 (85.7) 0.348 16 (57.1) 0.007
Age (median)
  < 21 years (40) 40 (100)   32 (80)  
  ≥ 21 years (40) 32 (80) 0.005 28 (70) 0.302
Site
 Femur (48) 44 (91.7)   36 (75)  
 Tibia (20) 16 (80)   12 (60)  
 Humerus (12) 12 (100) 0.232 12 (100) 0.041
Tumor Grade
 2 (16) 8 (50)   4 (25)  
 3 (64) 64 (100) <0.001* 56 (87.5) <0.001*
pTNM Stage
 I, II (44) 36 (81.8)   24 (54.5)  
 III, IV (36) 36 (100) 0.007 36 (100) <0.001*
Metastasis
 Present (20) 20 (100)   20 (100)  
 Absent (60) 52 (86.7) 0.085$ 40 (66.7) 0.003
  1. *Significant $Borderline significance (using intensity score)
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