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Fig. 4 | Applied Cancer Research

Fig. 4

From: What is new in Genitourinary Pathology? Recent developments and highlights of the new 2016 World Health Organization classification of tumors of the urinary system and male genital organs

Fig. 4

a HLRCC syndrome-associated RCC shows abundant eosinophilic cytoplasm, large nuclei and very prominent nucleoli with perinucleolar halos that resemble viral inclusions. b FH deficiency can be demonstrated by the lack of staining for FH on immunohistochemistry (only the background stromal cells are FH positive). c Typical appearances of SDH-deficient RCC with uniform low-grade cytology, cytoplasmic vacuoles, and eosinophilic or flocculent cytoplasm. d All SDH-deficient RCC show negative staining for SDHB on IHC; note the positive mast cells, which are often seen in the background

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