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Fig. 6 | Applied Cancer Research

Fig. 6

From: What is new in Genitourinary Pathology? Recent developments and highlights of the new 2016 World Health Organization classification of tumors of the urinary system and male genital organs

Fig. 6

a Clear cell carcinoma is a very rare penile carcinoma, which represents an example of HPV-related penile carcinoma. b Clear cell carcinoma demonstrates diffuse and strong staining for p16 on IHC. c Penile intraepithelial neoplasia (PeIN), a preneoplastic precursor lesion with dysplastic epithelial changes with non-HPV related (differentiated) PeIN features. d Squamous cell carcinoma of penis, Grade 2, is comprised of poorly differentiated areas with focal squamous differentiation (keratohyaline pearl)

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