Fig. 2

Histopathological and immunohistochemical comparison between AT/RT and MB in an independent set of tumors using TMAs. a H&E staining highlights the morphological characteristics of AT/RT and MB. While MB is predominantly represented by undifferentiated small blue round tumor cells, AT/RT displayed of rhabdoid phenotype (inserts: 40X). IHC for SMARCB1 showed loss of expression in AT/RT while expression is retained in MB. IHC for NCAM1 showed loss of expression in AT/RT with high expression levels at the cell membrane and extracellular spaces in MB. b Left: representative image of a TMA stained with NCAM1 antibody. Middle: the positive/negative ratio for NCAM1 in AT/RT samples. Right: the positive/negative ratio for NCAM1 in MB samples