Table 1 Patients' characteristics at diagnosis
Age at diagnosis | |
- Median (range) | 60 years (18–90) |
Sex | |
- Male - Female | n = 134 (52%) n = 126 (48%) |
ECOG performance status | |
- ECOG 0 - ECOG 1 - ECOG 2–3 - not evaluable | n = 136 (52%) n = 42 (16%) n = 7 (3%) n = 75 (29%) |
Comorbidities (age-adjusted CCI) | |
- CCI 2 - CCI 3–4 - CCI 5–6 - CCI ≥ 7 | n = 75 (29%) n = 88 (34%) n = 64 (25%) n = 33 (13%) |
Diagnostic work-up | |
- Blood count - Differential blood count - Bone marrow biopsy - Bone marrow aspirate | n = 245 (94%) n = 237 (91%) n = 212 (82%) n = 179 (69%) |
Methods of diagnosis | |
- Karyotyping (blood or bone marrow) - FISH-analysis (blood or bone marrow) - PCR-analysis (blood or bone marrow) | n = 225 (87%) n = 157 (60%) n = 205 (79%) |
EUTOS score (N = 130) | |
- High risk - Low risk | n = 26 (20%) n = 104 (80%) |
Phase of CML | |
- Chronic phase - Accelerated phase - Blast crisis | n = 254 (98%) n = 5 (2%) n = 1 (0.4%) |