From: SIVA, a target of p53, is downregulated in myelodysplastic syndromes
Factor | Univariate analysis | Multivariate analysis | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Event Free Survival | Overall Survival | Event Free Survival | Overall Survival | |||||||||
Hazard Ratiob | (95% C.I.) | p | Hazard Ratiob | (95% C.I.) | p | Hazard Ratiob | (95% C.I.) | p | Hazard Ratiob | (95% C.I.) | p | |
Gender | ||||||||||||
Male vs. female | 1.92 | 0.97–3.80 | 0.06 | 2.26 | 1.09–4.59 | 0.02 | 3.07 | 1.44–6.58 | 0.002 | 3.29 | 1.48–7.35 | 0.002 |
Age at sampling | 1.01 | 0.99–1.04 | 0.28 | 1.01 | 0.99–1.04 | 0.31 | - | - | - | - | - | - |
WHO 2008 classification | ||||||||||||
RAEB-1/RAEB-2 vs. others | 5.12 | 2.58–10.17 | <0.0001 | 3.95 | 1.94–8.06 | 0.002 | 8.54 | 3.66–19.93 | <0.0001 | 6.03 | 2.58–14.09 | 0.0004 |
Risk Stratification by IPSS-Ra | ||||||||||||
Intermediate/High/Very high vs. Very low/Low | 2.17 | 1.18–4.34 | 0.01 | 2.04 | 1.04–4.01 | 0.04 | - | - | - | - | - | - |
SIVA1 expression | 1.07 | 0.87–1.32 | 0.52 | 1.05 | 0.85–1.30 | 0.62 | - | - | - | - | - | - |
SIVA2 expression | 1.05 | 0.94–1.17 | 0.35 | 1.03 | 0.92–1.14 | 0.59 | - | - | - | - | - | - |
MDM2 expression | 0.80 | 0.63–1.01 | 0.06 | 0.79 | 0.62–1.02 | 0.07 | - | - | - | - | - | - |
TP53 expression | 1.02 | 0.97–1.08 | 0.46 | 1.02 | 0.96–1.09 | 0.43 | - | - | - | - | - | - |