Molecular binary classification of NSCLC: miR-375 is a potential biomarker to differentiate SQCC from ADCC in Indian NSCLC patients

Table 3 t Test and Mann-Whitney test

	Training set	miR-205	miR-196b	miR-375
^at-test of Ct value	SQCC: Mean ± SEM, n = 15	25.72 ± 1.392	28.34 ± 2.181	28.5 ± 1.059
	ADCC: Mean ± SEM, n = 15	27.75 ± 1.528	31.59 ± 0.9288	25.47 ± 1.013
	p Value	0.3340	0.1814	0.0478
	Validation set
	SQCC: Mean ± SEM, n = 31	24.72 ± 1.097	30.39 ± 0.6117	28.96 ± 0.717
	ADCC: Mean ± SEM, n = 29	26.55 ± 1.056	31.05 ± 0.8598	25.64 ± 0.8151
	p Value	0.2351	0.5293	0.0033
^bMann-Whitney test of sample score	Training set
	SQCC: Median, n = 15	0.4745	4.619	3.082
	ADCC: Median, n = 15	1.682	5.462	−1.694
	p Value	0.5875	0.9908	<0.0001
	Validation set
	SQCC: Median, n = 31	−0.4515	3.709	2.37
	ADCC: Median, n = 29	1.976	4.573	−0.413
	p Value	0.1534	0.2875	<0.0001

^at Test was done to check the significant difference between the mean Ct of SQCC and ADCC for the training set and validation set. ^bMann-Whitney test was done to check the significant difference between the median sample score of SQCC and ADCC for the training set and validation set