Table 6 SNPs observed in constitutively spliced KLK7 mRNAs expressed in breast cancer tissues
From: Down regulation of KLK7 expression in breast tissues and identification of a novel spliced KLK7 mRNA
Sr. no. | mRNA | Polymorphism | Position | Effect on sequence of encoded protein | Effect on 3D structure |
|---|---|---|---|---|---|
1 | SER2 | 1C+ | after 1540 | 16–241 amino acids align with the reference protein | Hydrolase, mannan-lectin serine protease1 |
A: C | 6321 | ||||
1C+ | after 6321 | ||||
G: A | 6326 | ||||
2 | SER3 | 1C+ | after 1540 | 16–241 amino acids align with the reference protein | Hydrolase, mannan-lectin serine protease1 |
A: C | 6321 | ||||
1G+ | after 6326 | ||||
3 | SER5 | TGCTCAGTG: CCCTTAAAA | 2047–2055 | 65–253 amino acids align with the reference protein | Hydrolase, plasminogen |
GAGCGCT: CCTTTTCA | 2091–2097 |