Table 2 Correlations between clinical and histopathological variables and VEGF or HIF1A expression
Variable | VEGF | HIF1A | ||||
|---|---|---|---|---|---|---|
Negative | Positive | Negative | Positive | |||
Stage | ||||||
II CRC | 8 (44.4) | 40 (49.4) | 13 (48.2) | 35 (48.6) | ||
0.705 | 0.967 | |||||
III CRC | 10 (55.6) | 41 (50.6) | 14 (51.8) | 37 (51.4) | ||
Histological grade | ||||||
Low grade | 6 (33.3) | 17 (21.2) | 8 (29.6) | 15 (21.1) | ||
0.355a | 0.375 | |||||
High grade | 12 (66.7) | 63 (78.8) | 19 (70.4) | 56 (78.9) | ||
Vascular invasion | ||||||
No | 12 (66.7) | 72 (88.9) | 23 (85.2) | 61 (84.7) | ||
0.028 a | 0.999a | |||||
Yes | 6 (33.3) | 9 (11.1) | 4 (14.8) | 11 (15.3) | ||
Perineural invasion | ||||||
No | 16 (88.9) | 62 (76.5) | 21 (77.8) | 57 (79.2) | ||
0.347a | 0.880 | |||||
Yes | 2 (11.1) | 19 (23.5) | 6 (22.2) | 15 (20.8) | ||
Lymphatic invasion | ||||||
No | 15 (83.3) | 58 (71.6) | 11 (40.7) | 15 (20.8) | ||
0.386a | 0.045 | |||||
Yes | 3 (16.7) | 23 (28.4) | 16 (59.3) | 57 (79.2) | ||