From: Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia
 | Immunohistochemical profile | Clinical course |
---|---|---|
Langerhans cell histocytosis and | CD1a+; S100 protein+; CD68−/+; lisozime-; CD21/CD35-; EBV-1 [Birbeck granules+] | Variable clinical presentation: localized indolent to systemic aggressive |
Langerhans cell sarcoma | Agressive | |
Indeterminate dendritic cell tumor | CD1a+; CD4+; Fascin+; S100+; CD68+/−; langerin [Birbeck granules–]- | Most frequently localized |
Interdigitating reticulum cell tumor | Positive: S100 protein, fascin; Frequently positive: CD4, CD11c, CD14, CD45, CD68, HLA-DR, lisozime, EMA; Negative: CD1a, langerin, CD21/CD35, CD23 | Mostly lymph nodes; very aggressive |
Follicular dendritic cell tumor | Positive: CD21/CD35, CD23, KiM4p, CNA42, clusterin, D2.40 (membrane), desmoplakin, fascin, EGFR, HLA-DR; Sometimes positive: CD4, CD11a, CD14, CD20, CD45, CD68, EMA, S100 protein, smooth muscle actin; IPT-like cases consistently EBV+; Negative: CD1a, CD3, CD34, CD79a, myeloperoxidase, lisozime, HMB45 | Mostly lymph nodes; middle age around the 5th decade; one third extranodal; moderately aggressive. IPT-like cases mostly liver and spleen, female patients, more indolent course. |
Fibroblastic reticular cell tumor / CIRC (cytokeratin positive interstitial reticular cell) tumor2 | Positive: Vimentin; CIRC: cytokeratins, EMA, CD21, fascin; Frequently positive: smooth muscle actin, desmin, factor XIIIa; Negative: CD35, D2.40, CD1a, S100, EBV | Indolent (localized cases) to aggressive |
Histiocytic sarcoma | Positive: CD68, CD163, CD4, CD11c, CD14, lysozyme; Negative: B and T cell markers, CD30, EMA, CD21, CD23, CD35, CD1a, langerin/CD207, CD13, CD33, myeloperoxidase, cytokeratins, HMB45; S100 protein positive in 50% cases | Frequently extranodal; Mostly aggressive |