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Table 2 Epithelial Profile

From: Mutational analysis of selected high-grade malignancies in a premenopausal gynecologic cancer population: a potential for targeted therapies?

n = 11 Genes associated with this histologic typec
Age APC ERBB2 NRAS
 Range 23–40    ARID1A FBXW7 PIK3CA
 Mean 33.9    BRAF FGFR2 PPP2R1A
 Median 36    BRCA1 KRAS PTEN
BMI BRCA2 MLH1 RNF43
 Range 24–61.4    CDKN2A MSH6 SMARCA4
 Mean 34    CTNNB1 MYC TP53
 Median 30    DNMT3A NF1  
Survival
 Range 369–660      
 Mean 542      
 Median 590      
   Chemo Rad Alive Novel Targets Profiles
Location   n = 7ab
Ovary 7 (64%) Carbo/Taxol 0 5 (71%) AKAP9 (3)
CMPK (1)
MBD1 (1)
ASXL1 (1)
ERBB3 (2)
KMT2D (1)
ERBB3 only (1)a
AKAP9 only (3)
CMPK, ASXL1 ERBB3 (1)
MBD1, KMT2D (1)
No significant genes (0)b
Cervix 2 (18%) Carbo/Taxol (1)
Plat/Etop (1)
1
1
2 (100%) 0 n/a
Endometrial 2 (18%) Carbo/Taxol 1 2 (100%) CMPK (1)
MBD1 (1)
ROS1 (1)
GPR124 (1)
CMPK, MBD1 (1)
ROS1, GPR124 (1)
  1. aindicates these profiles are associated with negative outcomes in our cohort; bone patient failed to have mutations in a significant gene; cdata and sources retrieved from http://cancer.sanger.ac.uk/cosmic