Skip to main content

Table 4 Sarcoma/Other Profile

From: Mutational analysis of selected high-grade malignancies in a premenopausal gynecologic cancer population: a potential for targeted therapies?

n = 5 Genes associated with this histologic typeb
Age BRCA2
 Range 15–39   CTNNB1
 Mean 25   EGFR
 Median 24   FOXL2
BMI c-KIT
 Range 20–46.6   P16
 Mean 31.6   TP53
 Median 23   
Survival
 Range 15–867   
 Mean 259.6   
 Median 182   
Cancer Type
 Sarcoma 3 Ovary (1) Endometrial (2)  
 Germ Cell 1 Ovary (1)  
 HG Sex Cord 1 Ovary (1)  
   Chemo Rad Alive Novel Targets Profiles
Location
 Ovary 3 Plat/Etoposide (1)
None (1)
Unknown (1)
0 1 (33%) MBD1 (1)
ROS1 (3)
EGFR (1)
ERBB3 (1)
KMT2D (1)
NTRK1 (1)
MBD1, ROS1 (1)
ROS1, EGFR (1)a
ROS1, ERBB3, KMT2D, NTRK1 (1)a
 Endometrial 2 Gemzar/Taxotere (1)
None (1)
0 1 (50%) CMPK1 (1)
MBD1 (1)
GPR124 (1)
CMPK1, MBD1 (1)
GPR124 (1)a
  1. aindicates these profiles are associated with negative outcomes in our cohort; bdata and sources retrieved from http://cancer.sanger.ac.uk/cosmic