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Table 5 Profiles associated with a negative outcome in our cohort

From: Mutational analysis of selected high-grade malignancies in a premenopausal gynecologic cancer population: a potential for targeted therapies?

Cancer Type Location Chemo Mutation Profile (significant genes) Mutation Loada APCb ABL2b
Epithelial Ovary Carbo/Taxol ERBB3 only (1) 22 neg neg
NE Ovary Plat/Etoposide ALK, GPR124, KMT2D (1) 27 neg neg
  Endometrial Carbo/Taxol ROS1, ALK, ERBB3, GPR124, KMT2D, NTRK1 (1) 111 neg neg
Sarcoma/Other Ovary Unknown
None 		ROS1, EGFR (1)
ROS1, ERBB3, KMT2D, NTRK1 (1) 		27
29 		neg neg
  Endometrial None GPR124 (1) 21 neg neg
  1. amutation load in our cohort based on the genes in our molecular profile; bneg indicates no mutation
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Applied Cancer Research

ISSN: 1980-5578

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