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Fig. 2 | Applied Cancer Research

Fig. 2

From: Splicing isoform-specific functional genomic in cancer cells

Fig. 2

Mechanism of action of Splicing modulators and Isoform-specific inhibitors. a A splicing modulator typically favor exon exclusion and can be designed as a a boundary-spanning (intron-exon) antisense, b covering an exon-intron junction, c on an exonic splicing enhancer, or d on an intronic splicing enhancer. A splicing modulator can also promote exon inclusion when masking e an exonic splicing silencer or f an intronic splicing silencer. g The TOSS is a fully exonic bifunctional splicing modulator that redirect splicing to favor exon exclusion. h The TOES is a fully exonic bifunctional splicing modulator that redirect splicing to favor exon inclusion. i The isoform-specific inhibitor (gapmer, siRNA) is design on the alternative sequence to decrease the long isoform expression. j The isoform-specific inhibitor (gapmer, siRNA) is design on the unique exon-exon junction of the short isoform to decrease its expression. Blue = Splicing enhancer sequence. Green = Splicing silencer sequence

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