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Table 1 Functional relationship between splicing isoforms of a gene

From: Splicing isoform-specific functional genomic in cancer cells

 

Scenario 1 (Monofunctional)

Scenario 2 (Antagonistic)

Scenario 3: (Redundancy)

Isoform A

Function A

Function A

Function A

Isoform B

No function

Function anti-A

Function A’

Phenotype dependent on

[A]

[A] / [B]

[A] + [B]

SM targeting Isoform A

Yes

Yes

No

SM targeting Isoform B

No

Yes (anti A)

No

ISI targeting A

Yes

Yes

Yes

ISI targeting B

No

Yes (anti A)

Yes

ISI targeting A and B

Yes

No

Yes

  1. Three theoric scenarios that fits most ASEs generating two isoforms. Yes phenotype, No no phenotype
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Applied Cancer Research

ISSN: 1980-5578