Table 4 Oligonucleotide-based strategies targeting Bcl-x and their capacity to induce apoptosis in human cancer cell lines
From: Splicing isoform-specific functional genomic in cancer cells
Human cancer cell line | Backbone chemistry | Induce apoptosis following a splicing shift from Bcl-xL to Bcl-xS | Induce apoptosis following an isoform specific inhibition of Bcl-xL |
|---|---|---|---|
A549 | 2’-MOE | No [118] | Yes [24] |
MCF-7 | PS-2’OMe | No [119] | Yes [120] |
MDA-MB-231 | PS-2’OMe | Yes [72] | Yes [120] |
HeLa | PS-2’OMe PNA-peptide | No [72] Yes [121] | N/A |
CaOV3 | N/A | N/A | Yes [122] |
PC-3 | PS-2’OMe 2’OMe (TOSS) | Yes [119] No [44] | N/A |
U87 | PS | Yes [123] | N/A |