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Table 4 Oligonucleotide-based strategies targeting Bcl-x and their capacity to induce apoptosis in human cancer cell lines

From: Splicing isoform-specific functional genomic in cancer cells

Human cancer cell line Backbone chemistry Induce apoptosis following a splicing shift from Bcl-xL to Bcl-xS Induce apoptosis following an isoform specific inhibition of Bcl-xL
A549 2’-MOE No [118] Yes [24]
MCF-7 PS-2’OMe No [119] Yes [120]
MDA-MB-231 PS-2’OMe Yes [72] Yes [120]
HeLa PS-2’OMe
PNA-peptide
No [72]
Yes [121]
N/A
CaOV3 N/A N/A Yes [122]
PC-3 PS-2’OMe
2’OMe (TOSS)
Yes [119]
No [44]
N/A
U87 PS Yes [123] N/A
  1. N/A Data not available