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Table 2 Association of p27kip1 expression with various clinicopathologic characteristics and prognostic parameters in patients with head and neck Squamous cell carcinoma

From: Low p27kip1 expression in head and neck squamous cell carcinoma: association with risk factors and adverse outcomes

Ā 

Low p27kip1 Expression (nā€‰=ā€‰39)

High p27kip1 Expression (nā€‰=ā€‰66)

P-Value

Relative Risk (95% CI)

Age(years)

Ā 

ā€ƒMeanā€‰Ā±ā€‰SDa

49.46ā€‰Ā±ā€‰14.13

51.83ā€‰Ā±ā€‰11.20

0.175**

NA

Groupsd

Ā 

ā€ƒā€‰ā‰¤ā€‰30ā€‰years

4(10.3)

2(3)

0.323**

NA

ā€ƒ31ā€“50ā€‰years

19(48.7)

32(48.5)

ā€ƒā€‰>ā€‰50ā€‰years

16(41)

32(48.5)

Tumor Size (cm)

Ā 

ā€ƒMeanā€‰Ā±ā€‰SDĀ°

3.80ā€‰Ā±ā€‰1.44

2.96ā€‰Ā±ā€‰1.44

0.056**

NA

Groupsc

Ā Ā Ā Ā 

ā€ƒT1(ā‰¤2ā€‰cm)

9(23.1)

18(27.3)

0.079**

NA

ā€ƒT2(2.1ā€“4.0ā€‰cm)

16(41)

37(56.1)

ā€ƒT3(>ā€‰4ā€‰cm)

14(35.9)

11(16.7)

Tumor Depth (cm)

Ā 

ā€ƒMeanā€‰Ā±ā€‰SDĀ°

1.04ā€‰Ā±ā€‰0.65

1.20ā€‰Ā±ā€‰0.79

0.534

NA

GroupsĀ®

Ā Ā Ā Ā 

ā€ƒā€‰<ā€‰2ā€‰cm

35(89.7)

54(81.8)

0.275**

0.514

(0.154ā€“1.723)

ā€ƒā€‰ā‰„ā€‰2ā€‰cm

4(10.3)

12(18.2)

Disease Free Survival (months)Ā°

16.08ā€‰Ā±ā€‰21.66

32.91ā€‰Ā±ā€‰25.37

0.000*

NA

History of Pan/gutka usage

Ā 

ā€ƒDuration (unit)b

15.72ā€‰Ā±ā€‰6.34

15.24ā€‰Ā±ā€‰10.28

0.532

NA

History of pan/gutkac

Ā 

ā€ƒYes

36(92.3)

45(68.2)

0.004*

0.179

(0.049ā€“0.647)

ā€ƒNo

3(7.7)

21(31.8)

Genderc

Ā Ā Ā Ā 

ā€ƒMale

31(79.5)

48(72.7)

0.438**

0.688

(0.267ā€“1.775)

ā€ƒFemale

8(20.5)

18(27.3)

Sited

Ā 

ā€ƒOral cavity proper/buccal mucosa

27(69.2)

44(66.7)

0.165

NA

ā€ƒLip

4(10.3)

1(1.5)

ā€ƒTongue

7(17.9)

17(25.8)

ā€ƒSoft Palate

1(2.6)

4(6.1)

Nodal Staged

Ā Ā 

ā€ƒN0

18(46.2)

36(54.5)

0.102**

NA

ā€ƒN1

3(7.7)

12(18.2)

ā€ƒN2b

17(43.6)

17(25.8)

ā€ƒN2c

1(2.6)

0(0)

ā€ƒN3

0(0)

1(1.5)

Extranodal extentionc

Ā Ā 

ā€ƒPresent

11(28.2)

18(27.3)

0.918**

1.048

(0.433ā€“2.534

ā€ƒNot Present

28(71.8)

48(72.7)

Histological Subtypesc

Ā Ā Ā Ā 

ā€ƒNon-keratinizing

7(17.9)

10(15.2)

0.738**

NA

ā€ƒKeratinizing

20(51.3)

39(59.1)

ā€ƒKeratinizing with maturation

12(30.8)

17(25.8)

Histological Graded

Ā 

ā€ƒGrade I

7(17.9)

18(27.3)

0.570**

NA

ā€ƒGrade II

28(71.8)

42(63.6)

ā€ƒGrade III

4(10.3)

6(9.1)

Lymphovascular Invasion

Ā 

ā€ƒPresent

0(0)

0(0)

NA

NA

ā€ƒNot Present

66(100)

39(100)

Perineural Invasionc

Ā 

Present

9(23.1)

7(10.6)

0.086**

2.529

(0.858ā€“7.454)

Not Present

30(76.9)

59(89.4)

Recurrencec

Ā 

Yes

29(74.4)

26(39.4)

0.001*

0.224

(0.094ā€“0.536)

No

10(25.6)

40(60.6)

  1. aIndependent t test was applied
  2. bMann-Whitney Test was applied
  3. cChi-Square Test was applied
  4. dFisher Exact Test was applied
  5. P-Valueā‰¤0.05, considered as significant
  6. *Significant at 0.05 level
  7. **Significant at 0.05 level