Table 1 Variant calls in samples untreated and treated with UDG. Number and percentage of transitions (Ts), transversions (Tv), and transition/transversion ratio (Ts/Tv) are shown for each sample. Mean value with standard deviation (Std Dev), confidence interval (CI) of 95% and paired t-test p-value are also shown
Trasition (Ts) | Transversion (Tv) | Ts/Tv ratio | |||||||
|---|---|---|---|---|---|---|---|---|---|
Samples | non UDG | with UDG | reduction (%) | non UDG | with UDG | reduction (%) | non UDG | with UDG | reduction (%) |
PP209 | 139 | 18 | 87 | 9 | 6 | 33 | 15.4 | 3 | 81 |
K2568 | 194 | 9 | 95 | 7 | 5 | 29 | 27.7 | 1.8 | 94 |
A11 | 220 | 37 | 83 | 9 | 12 | -33 | 24.4 | 3.1 | 87 |
A14 | 83 | 21 | 75 | 7 | 4 | 43 | 11.9 | 5.3 | 56 |
A19 | 24 | 7 | 71 | 3 | 3 | 0 | 8 | 2.3 | 71 |
A20 | 310 | NA | NA | 7 | NA | NA | 44.3 | NA | NA |
A25 | 338 | 28 | 92 | 9 | 3 | 67 | 37.6 | 9.3 | 75 |
A43 | 28 | 22 | 21 | 5 | 4 | 20 | 5.6 | 5.5 | 2 |
O10 | 179 | 30 | 83 | 5 | 6 | -20 | 35.8 | 5 | 86 |
O15 | 152 | 9 | 94 | 3 | 3 | 0 | 50.7 | 3 | 94 |
O16 | 144 | 20 | 86 | 7 | 9 | -29 | 20.6 | 2.2 | 89 |
O6 | 81 | 6 | 93 | 2 | 3 | -50 | 40.5 | 2 | 95 |
Mean (Std Dev) | 157.7 (99.1) | 18.8 (10.3) | 80 (21) | 6.1 (2.5) | 5.3 (2.9) | 5.5 (36.3) | 26.9 (14.9) | 3.9 (2.3) | 75.5 (27.1) |
CI (95%) | 82.7-204.9 | 11.9-25.7 | 65.9-94.1 | 4.3-7.7 | 3.3-7.2 | -18.8-29.8 | 15.5-35.1 | 2.4-5.4 | 57.28-93.6 |
p-value | 0.0007 | 0.3774 | 0.0007 | ||||||