Fig. 1

Overview of specific mutation and MMR status in primary tumors and matched single metastases. a. Liver metastases, b. Lung metastases. Grey bars: insufficient unique reads to confidently classify the paired sample as wildtype or mutant (this could be due to insufficient reads of either the primary tumor, the metastasis or both). The last two rows of the figure depict the exact number of samples and the percentage of samples. A percentage less than 1% is depicted with a “·”. Abbreviations: MMR: mismatch repair; MSI: microsatellite instable; MSS: microsatellite stable