Clinical significance of p27 Kip1 expression in advanced ovarian cancer

Applied Cancer Research

Table 1 Relation of expression of P27^KIP1 by Immunohistochemistry and RT-PCR and clinical and pathological data

	IHC						mRNA P27
	P27 + ve		P27 -ve				Upregulation of P27		Downregulation of P27
	N	%	N	%	t-test	P	N	%	N	%	t-test	P
Stage
IIIA^a	8	80	2	20	2.4	0.04	8	80	2	20	2.372	0.042
IIIB^a	10	83.3	2	16.7	3.09	0.01	10	83.3	2	16.7	3.093	0.01
IIIC^a	24	36.3	42	63.7	2.32	0.02	24	36.3	42	63.7	2.315	0.024
Grade
Moderate + Well differentiated	26	86.7	4	13.3	5.92	< 0.001	26	86.7	4	13.3	5.92	< 0.001
Poorly differentiated	16	27.6	42	72.4	3.82	< 0.001	16	27.6	42	72.4	3.816	< 0.001
Pathology
Serous	38	61.3	24	38.7	1.83	0.07	40	62.5	24	37.5	2.066	0.043
Non- serous	4	15.4	22	84.6	4.89	< 0.001	2	8.3	22	91.7	7.405	< 0.001
Ascites
Absent	24	85.7	4	14.3	5.92	< 0.001	24	85.7	4	14.3	5.396	< 0.001
Present	18	30	42	70	3.38	0.00	14	23.3	46	76.7	4.892	< 0.001
Response
CR, Microscopic disease, PR^a	40	87	6	13	7.46	< 0.001	41	89.1	5	10.9	8.509	< 0.001
No response or progressive disease	2	4.8	40	95.2	13.7	< 0.001	1	3.4	41	97.6	17.43	< 0.001
Residual Disease
> 2 cm	18	30	42	70	3.38	0.00	15	25	45	75	4.472	< 0.001
< 2 cm	24	85.7	4	14.3	5.4	< 0.001	21	75	7	25	3.055	0.005