Applied Cancer Research

Table 3 Comparison of P27kip1 assessment by immunohistochemistry, qRT-PCR, and different prognostic parameters

From: Clinical significance of p27 ^Kip1 expression in advanced ovarian cancer

	No.		RNA		IHC		X²	P
Stage			No	%	No	%
IIIA	10	Upreg^a or positive IHC^b	8	80	8	80	0.313	0.576
IIIA	10	Downreg.^c or negative IHC	2	20	2	20	0.313	0.576
IIIB	12	Upreg or positive IHC	10	83.3	10	83.3	0.3	0.584
IIIB	12	Downreg. or negative IHC	2	16.7	2	16.7	0.3	0.584
IIIC	66	Upreg or positive IHC	42	63.6	42	63.6	0.033	0.856
IIIC	66	Downreg. or negative IHC	24	36.4	24	36.4	0.033	0.856
Grade
Mod. + Well^d	30	Upreg or positive IHC	26	86.7	26	86.7	0.144	0.704
Mod. + Well^d	30	Downreg. or negative IHC	4	13.3	4	13.3	0.144	0.704
Poor	58	Upreg or positive IHC	16	27.6	16	27.6	0.043	0.835
Poor	58	Downreg. or negative IHC	42	72.4	42	72.4	0.043	0.835
Pathology
serous	64	Upreg or positive IHC	43	67.2	38	59.4	0.538	0.463
serous	64	Downreg. or negative IHC	21	32.8	26	40.6	0.538	0.463
NS^e	24	Upreg or positive IHC	2	8.3	4	16.7	0.19	0.663
NS^e	24	Downreg. or negative IHC	22	91.7	20	83.3	0.19	0.663
Ascites
present	60	Upreg or positive IHC	14	23.3	18	30	0.384	0.536
present	60	Downreg. or negative IHC	46	76.7	42	70	0.384	0.536
absent	28	Upreg or positive IHC	24	85.7	24	85.7	0.146	0.703
absent	28	Downreg. or negative IHC	4	14.3	4	14.3	0.146	0.703
Resid Dis^f
> 2 cm	60	Upreg or positive IHC	15	25	18	30	0.167	0.683
> 2 cm	60	Downreg. or negative IHC	45	75	42	70	0.167	0.683
< 2 cm	28	Upreg or positive IHC	21	75	24	85.7	0.453	0.501
< 2 cm	28	Downreg. or negative IHC	7	25	4	14.3	0.453	0.501
Response
CR, Micro dis., PR^g	46	Upreg or positive IHC	41	89.1	40	87	0	>.999
CR, Micro dis., PR^g	46	Downreg. or negative IHC	5	10.9	6	13	0	>.999
NR or progressive dis.^h	42	Upreg or positive IHC	1	2.4	2	4.8	0	>.999
NR or progressive dis.^h	42	Downreg. or negative IHC	41	97.6	40	95.2	0	>.999

^a Upregulation; ^b Immunohistochemistry; ^c downregulation; ^d Moderate and well-differentiated; ^e non-serous; ^f residual disease; ^g CR complete response, Micro dis.: microscopic disease, PR: partial response and ^h NR no response, progressive dis.: progressive disease

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