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Fig. 1 | Applied Cancer Research

Fig. 1

From: Regulatory lymphocytes: the dice that resolve the tumor endgame

Fig. 1

Mechanisms underlying Treg immune regulation in the tumor-microenvironment. Tregs express a unique complement of immunosuppressive molecules on their surfaces, including lymphocyte-activation gene-3 and ATP- and AMP-degrading enzymes. They also secrete immune regulatory modulators (such as granzyme B) and cytokines (IL10, TGFβ etc.), by which they can negatively regulate dendritic cells as well as cytotoxic T cells thereby facilitating tumor initiation and progression

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