Fig. 2
From: Regulatory lymphocytes: the dice that resolve the tumor endgame
The possible developmental sketch of Breg generation and the different functions played by this immunoregulatory subset of B cells. The interaction between conventional B and T cells can give rise to memory and plasma B cells whose primary function is to produce antibodies to fight against tumor antigens. This interaction might also give rise to immunosuppressive Bregs, which generally suppress Th1, Th17, and follicular helper T cells with the help of immunoregulatory modulators such as IL10, TGFβ, indoleamine 2,3-dioxygenase, and granzyme B