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  1. Tet methylcytosine dioxygenase 2 (TET2) is frequently mutated and/or downregulated in myeloid neoplasm, including myelodysplastic syndromes. Despite the extensive studies, the specific contribution of TET2 in ...

    Authors: Renata Scopim-Ribeiro, João Agostinho Machado-Neto, Adriana da Silva Santos Duarte, Fernando Ferreira Costa, Sara Teresinha Olalla Saad and Fabiola Traina

    Citation: Applied Cancer Research 2017 37:38

    Content type: Research article

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  2. Alternative splicing commonly occurs in cancer cells and many cancer specific splice variants have been reported as potential candidate biomarkers of the disease. We have studied human tissue Kallikrein 7 (KLK...

    Authors: Samina Ejaz, Faiz-ul-Hassan Nasim, Muhammad Ashraf and Gulzar Ahmad

    Citation: Applied Cancer Research 2017 37:35

    Content type: Research article

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  3. Cutaneous melanoma (CM) is the most aggressive subtype of skin cancer, with increasing incidence over the past several decades. DNA methylation is a key element of several biological processes such as genomic ...

    Authors: Dimitrius T. Pramio, André Y. Kashiwabara, Paula C. Pennacchi, Maria P. Rivas, Silvya S. Maria-Engler, Antônio H. J. F. M. Campos, João P. Duprat, Dirce M. Carraro and Ana C. V. Krepischi

    Citation: Applied Cancer Research 2017 37:34

    Content type: Research article

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  4. Melanoma is a metastatic type of skin cancer that is difficult to treat and the majority of efforts are directed to the design of new drugs. Medicinal Plants have been the primary source of medicines since lif...

    Authors: Sonam Pandey

    Citation: Applied Cancer Research 2017 37:33

    Content type: Research article

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  5. Pancreatic cancer has a poor prognosis. Patients might be better able to cope with their disease when the information is discussed that they consider most important. We investigated what questions pancreatic p...

    Authors: Lisa J. M. Ronde-Schoone, Chulja J. Pek, Rutger-Jan Swijnenburg and Arwen H. Pieterse

    Citation: Applied Cancer Research 2017 37:32

    Content type: Research article

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  6. In recent decades neoadjuvant therapies such as combined chemotherapy and radiotherapy have been introduced for cancer management. Compared with monotherapy modalities, neoadjuvant therapy is associated with g...

    Authors: Ali Ebrahimi Fard, M. B. Tavakoli, Hossein Salehi and Hamid Emami

    Citation: Applied Cancer Research 2017 37:29

    Content type: Research article

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  7. MIP is a cultivable, non-pathogenic organism, which shares several antigens with Mycobacterium tuberculosis and Mycobacterium leprae. It has several proposed clinical applications. However, its cytotoxic effect o...

    Authors: A. Darji, N. Desai, R. Modi, B. Khamar and S. Rajkumar

    Citation: Applied Cancer Research 2017 37:30

    Content type: Research article

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  8. Current developments in the targeted therapies of non-small-cell lung carcinoma demand accurate classification to dodge the adverse drug response and to yield maximum therapeutic outcome. Accurate classificati...

    Authors: Sangeet Bhaumik, Firoz Ahmad and Bibhu Ranjan Das

    Citation: Applied Cancer Research 2017 37:28

    Content type: Research article

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  9. Xerostomia or dry mouth is one of the most common and disturbing adverse effects following radiotherapy for head and neck cancer (HNC). This complication strongly increases the risk for dental caries, difficul...

    Authors: Graziella Chagas Jaguar, José Divaldo Prado, Daniel Campanhã and Fábio Abreu Alves

    Citation: Applied Cancer Research 2017 37:31

    Content type: Review

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  10. The aim of this study was to assess retrospectively treatment and outcome of CML-patients in community based oncology practices in Germany and whether European LeukemiaNET (ELN) recommendations were followed.

    Authors: Rudolf Weide, Bernhard Rendenbach, Monika Grundheber, Oswald Burkhard, Joachim Behringer, Michael Maasberg, Peter Ehscheidt, John W. Strehl, Richard Hansen and Stefan Feiten

    Citation: Applied Cancer Research 2017 37:26

    Content type: Research article

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  11. Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms, comprising 0.3 – 1.0% of all primary breast malignancies in Western countries, but accounting for a higher proportion of primary br...

    Authors: Valerie Cui Yun Koh, Aye Aye Thike and Puay Hoon Tan

    Citation: Applied Cancer Research 2017 37:15

    Content type: Review

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  12. Gastric carcinoma (GC) is the third leading cause of death among malignant tumors worldwide, causing approximately 900,000 deaths/year. Changes in oncogenes that encode tyrosine kinase receptors play an import...

    Authors: Bianca Della Croce Vieira Cota, Karine Sampaio Lima, André Márcio Murad, Marcelo Antônio Pascoal Xavier, Mônica Maria Demas Álvares Cabral and Luiz Gonzaga Vaz Coelho

    Citation: Applied Cancer Research 2017 37:18

    Content type: Research article

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  13. Current methods for follow-up of Ovarian Cancer (OC) are widespread, especially with CA125, which, however, is not a perfect biomarker and thus further investigation for new methods of evaluation are warranted...

    Authors: Marcelo Corassa, Andrea Paiva Gadelha Guimarães, Solange Moraes Sanches, Marcello Ferretti Fanelli, Bruna Maria M. Rocha, Alexandre Andre Balieiro A. da Costa, Vanessa Alves, Glauco Baiocchi and Ludmilla T. Domingos Chinen

    Citation: Applied Cancer Research 2017 37:12

    Content type: Case report

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  14. The medical management of low-grade squamous intraepithelial lesions (LSIL) is variable, thus a biomarker could assist with the clinical conduct. Type 2 transglutaminase (TG2) has been proposed as a cellular-i...

    Authors: Karen Olivia Bazzo Goulart, Alessandra Eifler Guerra Godoy, Isnard Elman Litvin and Fábio Firmbach Pasqualotto

    Citation: Applied Cancer Research 2017 37:27

    Content type: Research article

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  15. SIVA is a transcriptional target of p53 that plays a potential role in the development and progression of cancer. In this study, we analyzed SIVA1 and SIVA2 expression, and its associa...

    Authors: João Agostinho Machado-Neto, Paula de Melo Campos, Patricia Favaro, Mariana Lazarini, Renata Scopim-Ribeiro, Irene Lorand-Metze, Fernando Ferreira Costa, Sara Terezinha Olalla Saad and Fabiola Traina

    Citation: Applied Cancer Research 2017 37:25

    Content type: Research article

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  16. Polyamines present in human body are frequently considered as markers of occurrence of cancer. Therefore, the availability of simple and efficient method for determination of their level in body liquids and ti...

    Authors: Waldemar Balcerzak, Katarzyna Pokajewicz and Piotr P. Wieczorek

    Citation: Applied Cancer Research 2017 37:23

    Content type: Research article

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  17. Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive embryonal tumors of the central nervous system. They are largely characterized by inactivating mutations of the SMARCB1 tumor suppressor gene. AT/RT patien...

    Authors: Mario Suzuki, Kashyap Patel, Chiang-Ching Huang, Felipe D’Almeida Costa, Akihide Kondo, Fernando Augusto Soares, Tadanori Tomita and Simone Treiger Sredni

    Citation: Applied Cancer Research 2017 37:14

    Content type: Research article

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  18. Cancer cachexia is a debilitating paraneoplastic syndrome featuring unintended weight loss and skeletal muscle atrophy. Evidence suggests that bone health may also be compromised, further limiting mobility and...

    Authors: Andy V. Khamoui, Ming-Chia Yeh, Do-Houn Kim, Bong-Sup Park, Marcus L. Elam, Edward Jo, Bahram H. Arjmandi and Jeong-Su Kim

    Citation: Applied Cancer Research 2017 37:17

    Content type: Research article

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  19. Gastrointestinal stromal tumors (GISTs) originate as precursor cells of the interstitial cells of Cajal in the myenteric plexus and generally have a mutation in the tyrosine kinase receptor, C-KIT (CD117). The...

    Authors: Erinaldo Rocha Paes Landim, Carolina de Barros Jaqueta, Rubens Chojniak, Felipe José Fernandez Coimbra, Celso Abdon Lopes de Mello, Patricia Oriani, Almir Galvão Vieira Bitencourt and Luana de Paula Silva Paes

    Citation: Applied Cancer Research 2017 37:21

    Content type: Research article

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  20. Anal cancer malignancies comprise about 1.5 to 3% of cancers from the gastrointestinal in which high-risk types of human papillomavirus (HR-HPV) is responsible for >80% of cases. The aim of this work was to de...

    Authors: Sulayne Janayna Araujo Guimarães, Flávia Castello Branco Vidal, Jéssica Maran Cavalcante Soares, Maria do Desterro Soares Brandão Nascimento, Luísa Lina Villa and Luciane Maria Oliveira Brito

    Citation: Applied Cancer Research 2017 37:19

    Content type: Research article

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  21. Tertiary care cancer centers can act as reference units for prevention and early detection programs. The purpose of this study was to describe the profile of the Cancer Prevention Campaign (CPC) participants a...

    Authors: Diego Fernandes dos Santos, Maria Paula Curado and Diego Rodrigues Mendonça e Silva

    Citation: Applied Cancer Research 2017 37:24

    Content type: Research article

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  22. Acute myeloid leukemia (AML) is a clonal hematologic neoplasm characterized by heterogeneity of genetic abnormalities found at diagnosis. These abnormalities serve to classify patients by risk group into low, ...

    Authors: Silvia Elena Sánchez-Mendoza and Eduardo M. Rego

    Citation: Applied Cancer Research 2017 37:22

    Content type: Review

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  23. Primary liver cancers are rare in children, and the most common type is hepatoblastoma (HB), an embryonal tumor with histological features that resemble different stages of liver cell differentiation. However,...

    Authors: Talita Ferreira Marques Aguiar, Thaise Nayane Carneiro, Cecilia Maria Lima da Costa, Carla Rosenberg, Isabela Werneck da Cunha and Ana Cristina Victorino Krepischi

    Citation: Applied Cancer Research 2017 37:20

    Content type: Review

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  24. To evaluate the imaging findings in patients with breast cancer diagnosed before age 40 and their correlation with histological type and molecular subtype.

    Authors: Deise Santiago Girão Eugênio, Juliana Alves Souza, Rubens Chojniak, Almir Galvão Vieira Bitencourt, Luciana Graziano and Elvira Ferreira Marques

    Citation: Applied Cancer Research 2017 37:16

    Content type: Research article

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  25. Myelodysplastic syndromes (MDS) are a heterogeneous group of disorders characterized by ineffective hematopoiesis and risk of leukemia transformation. There is evidence to suggest the participation of immune s...

    Authors: Matheus Rodrigues Lopes, João Kleber Novais Pereira, Fabiola Traina, Paula de Melo Campos, João Agostinho Machado-Neto, Sara Teresinha Olalla Saad and Patricia Favaro

    Citation: Applied Cancer Research 2017 37:9

    Content type: Research article

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  26. Apoptosis-related gene expression such as BCL2, and p53 has been suggested in predicting the patient response to chemo- or radiotherapy, as well as patient’s survival.

    Authors: Hiwa K. Saaed, Matin A. Mahmood and Najmaddin Khoshnaw

    Citation: Applied Cancer Research 2017 37:8

    Content type: Research article

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  27. Cancer is rapidly growing to be one of the major health burdens in Brazil and Latin America. Access to tumor samples is one of the many barriers that need to be removed in order to promote clinical and transla...

    Authors: Antonio Hugo Jose Froes Marques Campos, Dirce Maria Carraro and Fernando Augusto Soares

    Citation: Applied Cancer Research 2017 37:6

    Content type: Review

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  28. OSF is a potentially malignant condition affecting the oral cavity and oropharynx. MMP-3 also known as Stromelysin -I is a key member of the MMP family which is responsible for degradation of collagen type II,...

    Authors: Preethi A. Poonja, Atul P. Sattur, Krishna N. Burde and Shivaprakash V. Hiremath

    Citation: Applied Cancer Research 2017 37:4

    Content type: Research Article

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  29. Basaloid carcinomas of the penis, HPV-related tumors, are morphologically less homogenous than originally thought. The study objective was to evaluate the prognostic influence of the basaloid pattern in mixed ...

    Authors: Isabel Alvarado-Cabrero, Diego Fernando Sanchez, Diana Piedras, Adriana Rodriguez-Gómez, Ingrid M. Rodriguez, Maria Jose Fernandez-Nestosa, Narciso Hernández-Toriz and Antonio L. Cubilla

    Citation: Applied Cancer Research 2017 37:3

    Content type: Research article

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  30. Oral squamous cell carcinoma (OSCC) is the eighth most prevalent cancer worldwide. In recent large-scale studies, by immunohistochemistry and cluster analysis, several markers were associated with patient surv...

    Authors: Cláudia Malheiros Coutinho-Camillo, Silvia Vanessa Lourenço, Renato David Puga, Aline Santos Damascena, Tathyane Harumi Nakajima Teshima, Luiz Paulo Kowalski and Fernando Augusto Soares

    Citation: Applied Cancer Research 2017 37:2

    Content type: Research article

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  31. Current strategies for cancer patient management include the use of genomic and proteomic test results to help guide therapeutic selection. The need for multi-target variant analysis is highlighted by the grow...

    Authors: Hou-Sung Jung, Joel A. Lefferts and Gregory J. Tsongalis

    Citation: Applied Cancer Research 2017 37:1

    Content type: Review

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  32. Muscle invasive bladder cancer (BC) has a mortality rate of 50% in 5 years, despite the aggressive treatments currently used. The diagnosis of latent tumor cells in histologically normal lymph nodes (LN) may h...

    Authors: Gustavo Cuck, Isabela Werneck da Cunha, Walter Henriques da Costa, Clóvis Antônio Lopes Pinto, Carlos Alberto Ricetto Sacomani, Francisco Paulo da Fonseca and Gustavo Cardoso Guimarães

    Citation: Applied Cancer Research 2016 36:6

    Content type: Research article

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  33. Vitamin D (VD) is a secosteroid hormone that is mainly synthesized in the skin upon exposure to UVB radiation. VD is widely known for its role in calcium metabolism; however, multiple endocrine, paracrine and ...

    Authors: Constanza Del Puerto, Cristián Navarrete-Dechent, Montserrat Molgó, Arturo Borzutzky and Sergio González

    Citation: Applied Cancer Research 2016 36:5

    Content type: Review

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  34. The conventional osteosarcoma (OS) is the commonest primary malignant, bone tumor with complex genomic profiles and poor survival. Runt-related transcription factor 2 (RUNX2) and WW domain containing oxidoreducta...

    Authors: Abeer A. Bahnassy, Eman Abdelzaher, Rania Gaber, Gamal Elhosseiny, Awad Abdel Moniem A. Rafalla, Abdel-rahman N. Zekri, Ahmad El-Bastawisi, Hend F. Yousif and Layla Kamal Younis

    Citation: Applied Cancer Research 2016 36:4

    Content type: Research article

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  35. The recently published 2016 World Health Organization (WHO) Classification of Tumors of the Urinary System and Male Genital Organs stems from the accumulated knowledge and data collected during the last 12 yea...

    Authors: Daniel Abensur Athanazio and Kiril Trpkov

    Citation: Applied Cancer Research 2016 36:1

    Content type: Review

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  36. Quality assurance and peer-review practices in surgical pathology have been well described in the literature, but the majority of these reports apply to the realm of general surgical pathology. We focused on t...

    Authors: David J. Dabbs, Catherine T. Stoos and Abbie Mallon

    Citation: Applied Cancer Research 2016 36:3

    Content type: Research article

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