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  1. Research article

    SIVA, a target of p53, is downregulated in myelodysplastic syndromes

    SIVA is a transcriptional target of p53 that plays a potential role in the development and progression of cancer. In this study, we analyzed SIVA1 and SIVA2 expression, and its associa...

    João Agostinho Machado-Neto, Paula de Melo Campos, Patricia Favaro, Mariana Lazarini, Renata Scopim-Ribeiro, Irene Lorand-Metze, Fernando Ferreira Costa, Sara Terezinha Olalla Saad and Fabiola Traina

    Applied Cancer Research 2017 37:25

    Published on: 15 June 2017

  2. Research article

    Loss of expression of the Neural Cell Adhesion Molecule 1 (NCAM1) in atypical teratoid/rhabdoid tumors: a new diagnostic marker?

    Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive embryonal tumors of the central nervous system. They are largely characterized by inactivating mutations of the SMARCB1 tumor suppressor gene. AT/RT patien...

    Mario Suzuki, Kashyap Patel, Chiang-Ching Huang, Felipe D’Almeida Costa, Akihide Kondo, Fernando Augusto Soares, Tadanori Tomita and Simone Treiger Sredni

    Applied Cancer Research 2017 37:14

    Published on: 9 June 2017

  3. Research article

    Bone mineral density and content are differentially impacted by aerobic and resistance training in the colon-26 mouse model of cancer cachexia

    Cancer cachexia is a debilitating paraneoplastic syndrome featuring unintended weight loss and skeletal muscle atrophy. Evidence suggests that bone health may also be compromised, further limiting mobility and...

    Andy V. Khamoui, Ming-Chia Yeh, Do-Houn Kim, Bong-Sup Park, Marcus L. Elam, Edward Jo, Bahram H. Arjmandi and Jeong-Su Kim

    Applied Cancer Research 2017 37:17

    Published on: 8 June 2017

  4. Research article

    Gastrointestinal stromal tumors treated at a Brazilian Cancer Center: evaluation of clinical, epidemiological, and therapeutic profiles

    Gastrointestinal stromal tumors (GISTs) originate as precursor cells of the interstitial cells of Cajal in the myenteric plexus and generally have a mutation in the tyrosine kinase receptor, C-KIT (CD117). The...

    Erinaldo Rocha Paes Landim, Carolina de Barros Jaqueta, Rubens Chojniak, Felipe José Fernandez Coimbra, Celso Abdon Lopes de Mello, Patricia Oriani, Almir Galvão Vieira Bitencourt and Luana de Paula Silva Paes

    Applied Cancer Research 2017 37:21

    Published on: 7 June 2017

  5. Research article

    Prevalence of human papillomavirus infection in squamous cell carcinoma of the anal canal in a Northeast City in Brazil: viral genotyping and clinical aspects

    Anal cancer malignancies comprise about 1.5 to 3% of cancers from the gastrointestinal in which high-risk types of human papillomavirus (HR-HPV) is responsible for >80% of cases. The aim of this work was to de...

    Sulayne Janayna Araujo Guimarães, Flávia Castello Branco Vidal, Jéssica Maran Cavalcante Soares, Maria do Desterro Soares Brandão Nascimento, Luísa Lina Villa and Luciane Maria Oliveira Brito

    Applied Cancer Research 2017 37:19

    Published on: 6 June 2017

  6. Research article

    Cancer detection ratio in a population participating in cancer screening programs at a tertiary care cancer center in São Paulo

    Tertiary care cancer centers can act as reference units for prevention and early detection programs. The purpose of this study was to describe the profile of the Cancer Prevention Campaign (CPC) participants a...

    Diego Fernandes dos Santos, Maria Paula Curado and Diego Rodrigues Mendonça e Silva

    Applied Cancer Research 2017 37:24

    Published on: 2 June 2017

  7. Review

    Targeting the mitochondria in acute myeloid leukemia

    Acute myeloid leukemia (AML) is a clonal hematologic neoplasm characterized by heterogeneity of genetic abnormalities found at diagnosis. These abnormalities serve to classify patients by risk group into low, ...

    Silvia Elena Sánchez-Mendoza and Eduardo M. Rego

    Applied Cancer Research 2017 37:22

    Published on: 23 May 2017

  8. Review

    The genetic and epigenetic landscapes of hepatoblastomas

    Primary liver cancers are rare in children, and the most common type is hepatoblastoma (HB), an embryonal tumor with histological features that resemble different stages of liver cell differentiation. However,...

    Talita Ferreira Marques Aguiar, Thaise Nayane Carneiro, Cecilia Maria Lima da Costa, Carla Rosenberg, Isabela Werneck da Cunha and Ana Cristina Victorino Krepischi

    Applied Cancer Research 2017 37:20

    Published on: 23 May 2017

  9. Research article

    Breast cancer diagnosed before the 40 years: imaging findings and correlation with histology and molecular subtype

    To evaluate the imaging findings in patients with breast cancer diagnosed before age 40 and their correlation with histological type and molecular subtype.

    Deise Santiago Girão Eugênio, Juliana Alves Souza, Rubens Chojniak, Almir Galvão Vieira Bitencourt, Luciana Graziano and Elvira Ferreira Marques

    Applied Cancer Research 2017 37:16

    Published on: 12 May 2017

  10. Review

    Current applications of molecular pathology in colorectal carcinoma

    Molecular pathology is playing an increasingly important role in the treatment and overall management of patients with colorectal carcinoma. Three distinct genetic pathways have been identified that play a rol...

    Raul S. Gonzalez, Kay Washington and Chanjuan Shi

    Applied Cancer Research 2017 37:13

    Published on: 11 May 2017

  11. Research article

    IL32 expression in peripheral blood CD3+ cells from myelodysplastic syndromes patients

    Myelodysplastic syndromes (MDS) are a heterogeneous group of disorders characterized by ineffective hematopoiesis and risk of leukemia transformation. There is evidence to suggest the participation of immune s...

    Matheus Rodrigues Lopes, João Kleber Novais Pereira, Fabiola Traina, Paula de Melo Campos, João Agostinho Machado-Neto, Sara Teresinha Olalla Saad and Patricia Favaro

    Applied Cancer Research 2017 37:9

    Published on: 5 May 2017

  12. Review

    Genomics and epidemiology for gastric adenocarcinomas

    Whereas the pathological aspects of Gastric Adenocarcinomas (GACs) have been well defined, the actual knowledge of its genesis and evolution remains to be translated to better diagnosis and to more effective t...

    Applied Cancer Research 2017 37:7

    Published on: 10 March 2017

    The Erratum to this article has been published in Applied Cancer Research 2017 37:11

  13. Research Article

    A study on genetic polymorphism in Matrix Metalloproteinases-3 in oral submucous fibrosis patients and in healthy individuals

    OSF is a potentially malignant condition affecting the oral cavity and oropharynx. MMP-3 also known as Stromelysin -I is a key member of the MMP family which is responsible for degradation of collagen type II,...

    Preethi A. Poonja, Atul P. Sattur, Krishna N. Burde and Shivaprakash V. Hiremath

    Applied Cancer Research 2017 37:4

    Published on: 28 February 2017

  14. Research article

    The variable morphological spectrum of penile basaloid carcinomas: differential diagnosis, prognostic factors and outcome report in 27 cases classified as classic and mixed variants

    Basaloid carcinomas of the penis, HPV-related tumors, are morphologically less homogenous than originally thought. The study objective was to evaluate the prognostic influence of the basaloid pattern in mixed ...

    Isabel Alvarado-Cabrero, Diego Fernando Sanchez, Diana Piedras, Adriana Rodriguez-Gómez, Ingrid M. Rodriguez, Maria Jose Fernandez-Nestosa, Narciso Hernández-Toriz and Antonio L. Cubilla

    Applied Cancer Research 2017 37:3

    Published on: 22 February 2017

  15. Research article

    Profile of apoptotic proteins in oral squamous cell carcinoma: A cluster analysis of 171 cases

    Oral squamous cell carcinoma (OSCC) is the eighth most prevalent cancer worldwide. In recent large-scale studies, by immunohistochemistry and cluster analysis, several markers were associated with patient surv...

    Cláudia Malheiros Coutinho-Camillo, Silvia Vanessa Lourenço, Renato David Puga, Aline Santos Damascena, Tathyane Harumi Nakajima Teshima, Luiz Paulo Kowalski and Fernando Augusto Soares

    Applied Cancer Research 2017 37:2

    Published on: 24 January 2017

  16. Review

    Utilization of the oncoscan microarray assay in cancer diagnostics

    Current strategies for cancer patient management include the use of genomic and proteomic test results to help guide therapeutic selection. The need for multi-target variant analysis is highlighted by the grow...

    Hou-Sung Jung, Joel A. Lefferts and Gregory J. Tsongalis

    Applied Cancer Research 2017 37:1

    Published on: 10 January 2017

  17. Research article

    Diagnosis of micrometastasis in muscle invasive bladder cancer through immunohistochemistry analysis: is there indication for routine evaluation?

    Muscle invasive bladder cancer (BC) has a mortality rate of 50% in 5 years, despite the aggressive treatments currently used. The diagnosis of latent tumor cells in histologically normal lymph nodes (LN) may h...

    Gustavo Cuck, Isabela Werneck da Cunha, Walter Henriques da Costa, Clóvis Antônio Lopes Pinto, Carlos Alberto Ricetto Sacomani, Francisco Paulo da Fonseca and Gustavo Cardoso Guimarães

    Applied Cancer Research 2016 36:6

    Published on: 15 December 2016

  18. Review

    Vitamin D axis and its role in skin carcinogenesis: a comprehensive review

    Vitamin D (VD) is a secosteroid hormone that is mainly synthesized in the skin upon exposure to UVB radiation. VD is widely known for its role in calcium metabolism; however, multiple endocrine, paracrine and ...

    Constanza Del Puerto, Cristián Navarrete-Dechent, Montserrat Molgó, Arturo Borzutzky and Sergio González

    Applied Cancer Research 2016 36:5

    Published on: 8 December 2016

  19. Research article

    RUNX2 and WWOX genes as molecular biomarkers and candidates for targeted therapy in Egyptian patients with primary conventional osteosarcoma

    The conventional osteosarcoma (OS) is the commonest primary malignant, bone tumor with complex genomic profiles and poor survival. Runt-related transcription factor 2 (RUNX2) and WW domain containing oxidoreducta...

    Abeer A. Bahnassy, Eman Abdelzaher, Rania Gaber, Gamal Elhosseiny, Awad Abdel Moniem A. Rafalla, Abdel-rahman N. Zekri, Ahmad El-Bastawisi, Hend F. Yousif and Layla Kamal Younis

    Applied Cancer Research 2016 36:4

    Published on: 8 December 2016

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