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Applied Cancer Research

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  1. Content type: Research article

    It is expected that about 65,000 new patients will be diagnosed with head and neck cancer in 2017 in the United States. Patients with recurrent or advanced or metastatic head and neck do not have good survival...

    Authors: Rohit Bishnoi, Chintan Shah, Harini Bejjanki, Jeffery A. Bennett and David N. Reisman

    Citation: Applied Cancer Research 2017 37:43

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  2. Content type: Research article

    The development of oral cavity cancer is related to the accumulation of genetic alterations. The activation of AKT is associated with the proliferation and progression of many malignancies. It is thought that ...

    Authors: Darkle Modesto Ferreira, Tercia J. Neves, Luiz Guilherme C. A. Lima, Fabio A. Alves and Maria D. Begnami

    Citation: Applied Cancer Research 2017 37:41

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  3. Content type: Research article

    Functional speech rehabilitation after total laryngectomy remains one of the most challenging issues in head and neck multidisciplinary care. Tracheoesophageal puncture for voice prosthesis insertion performed...

    Authors: Adriane Graicer Pelosof, Alvaro Moura Seraphim, Claudia Zitron Sztokfisz, Jose Guilherme Vartanian and Luiz Paulo Kowalski

    Citation: Applied Cancer Research 2017 37:42

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  4. Content type: Research article

    Patients with stage II CRC have a varying survival outcome. Therefore, it is critical to identify prognostic biomarkers that can define more aggressive forms of the disease. We assessed the expression levels o...

    Authors: Abeer A. Bahnassy, Mohammad El-Sayed, Nasr M. Ali, Ola Khorshid, Marwa M. Hussein, Hend F. Yousef, Marwa A. Mohanad, Abdel-Rahman N. Zekri and Salem E. Salem

    Citation: Applied Cancer Research 2017 37:39

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  5. Content type: Research article

    Tet methylcytosine dioxygenase 2 (TET2) is frequently mutated and/or downregulated in myeloid neoplasm, including myelodysplastic syndromes. Despite the extensive studies, the specific contribution of TET2 in ...

    Authors: Renata Scopim-Ribeiro, João Agostinho Machado-Neto, Adriana da Silva Santos Duarte, Fernando Ferreira Costa, Sara Teresinha Olalla Saad and Fabiola Traina

    Citation: Applied Cancer Research 2017 37:38

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  6. Content type: Research article

    Alternative splicing commonly occurs in cancer cells and many cancer specific splice variants have been reported as potential candidate biomarkers of the disease. We have studied human tissue Kallikrein 7 (KLK...

    Authors: Samina Ejaz, Faiz-ul-Hassan Nasim, Muhammad Ashraf and Gulzar Ahmad

    Citation: Applied Cancer Research 2017 37:35

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  7. Content type: Research article

    Cutaneous melanoma (CM) is the most aggressive subtype of skin cancer, with increasing incidence over the past several decades. DNA methylation is a key element of several biological processes such as genomic ...

    Authors: Dimitrius T. Pramio, André Y. Kashiwabara, Paula C. Pennacchi, Maria P. Rivas, Silvya S. Maria-Engler, Antônio H. J. F. M. Campos, João P. Duprat, Dirce M. Carraro and Ana C. V. Krepischi

    Citation: Applied Cancer Research 2017 37:34

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  8. Content type: Research article

    Melanoma is a metastatic type of skin cancer that is difficult to treat and the majority of efforts are directed to the design of new drugs. Medicinal Plants have been the primary source of medicines since lif...

    Authors: Sonam Pandey

    Citation: Applied Cancer Research 2017 37:33

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  9. Content type: Research article

    Pancreatic cancer has a poor prognosis. Patients might be better able to cope with their disease when the information is discussed that they consider most important. We investigated what questions pancreatic p...

    Authors: Lisa J. M. Ronde-Schoone, Chulja J. Pek, Rutger-Jan Swijnenburg and Arwen H. Pieterse

    Citation: Applied Cancer Research 2017 37:32

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  10. Content type: Research article

    In recent decades neoadjuvant therapies such as combined chemotherapy and radiotherapy have been introduced for cancer management. Compared with monotherapy modalities, neoadjuvant therapy is associated with g...

    Authors: Ali Ebrahimi Fard, M. B. Tavakoli, Hossein Salehi and Hamid Emami

    Citation: Applied Cancer Research 2017 37:29

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  11. Content type: Research article

    MIP is a cultivable, non-pathogenic organism, which shares several antigens with Mycobacterium tuberculosis and Mycobacterium leprae. It has several proposed clinical applications. However, its cytotoxic effect o...

    Authors: A. Darji, N. Desai, R. Modi, B. Khamar and S. Rajkumar

    Citation: Applied Cancer Research 2017 37:30

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  12. Content type: Research article

    Current developments in the targeted therapies of non-small-cell lung carcinoma demand accurate classification to dodge the adverse drug response and to yield maximum therapeutic outcome. Accurate classificati...

    Authors: Sangeet Bhaumik, Firoz Ahmad and Bibhu Ranjan Das

    Citation: Applied Cancer Research 2017 37:28

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  13. Content type: Review

    Xerostomia or dry mouth is one of the most common and disturbing adverse effects following radiotherapy for head and neck cancer (HNC). This complication strongly increases the risk for dental caries, difficul...

    Authors: Graziella Chagas Jaguar, José Divaldo Prado, Daniel Campanhã and Fábio Abreu Alves

    Citation: Applied Cancer Research 2017 37:31

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  14. Content type: Research article

    The aim of this study was to assess retrospectively treatment and outcome of CML-patients in community based oncology practices in Germany and whether European LeukemiaNET (ELN) recommendations were followed.

    Authors: Rudolf Weide, Bernhard Rendenbach, Monika Grundheber, Oswald Burkhard, Joachim Behringer, Michael Maasberg, Peter Ehscheidt, John W. Strehl, Richard Hansen and Stefan Feiten

    Citation: Applied Cancer Research 2017 37:26

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  15. Content type: Review

    Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms, comprising 0.3 – 1.0% of all primary breast malignancies in Western countries, but accounting for a higher proportion of primary br...

    Authors: Valerie Cui Yun Koh, Aye Aye Thike and Puay Hoon Tan

    Citation: Applied Cancer Research 2017 37:15

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  16. Content type: Case report

    Current methods for follow-up of Ovarian Cancer (OC) are widespread, especially with CA125, which, however, is not a perfect biomarker and thus further investigation for new methods of evaluation are warranted...

    Authors: Marcelo Corassa, Andrea Paiva Gadelha Guimarães, Solange Moraes Sanches, Marcello Ferretti Fanelli, Bruna Maria M. Rocha, Alexandre Andre Balieiro A. da Costa, Vanessa Alves, Glauco Baiocchi and Ludmilla T. Domingos Chinen

    Citation: Applied Cancer Research 2017 37:12

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  17. Content type: Research article

    Gastric carcinoma (GC) is the third leading cause of death among malignant tumors worldwide, causing approximately 900,000 deaths/year. Changes in oncogenes that encode tyrosine kinase receptors play an import...

    Authors: Bianca Della Croce Vieira Cota, Karine Sampaio Lima, André Márcio Murad, Marcelo Antônio Pascoal Xavier, Mônica Maria Demas Álvares Cabral and Luiz Gonzaga Vaz Coelho

    Citation: Applied Cancer Research 2017 37:18

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  18. Content type: Research article

    The medical management of low-grade squamous intraepithelial lesions (LSIL) is variable, thus a biomarker could assist with the clinical conduct. Type 2 transglutaminase (TG2) has been proposed as a cellular-i...

    Authors: Karen Olivia Bazzo Goulart, Alessandra Eifler Guerra Godoy, Isnard Elman Litvin and Fábio Firmbach Pasqualotto

    Citation: Applied Cancer Research 2017 37:27

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  19. Content type: Research article

    SIVA is a transcriptional target of p53 that plays a potential role in the development and progression of cancer. In this study, we analyzed SIVA1 and SIVA2 expression, and its associa...

    Authors: João Agostinho Machado-Neto, Paula de Melo Campos, Patricia Favaro, Mariana Lazarini, Renata Scopim-Ribeiro, Irene Lorand-Metze, Fernando Ferreira Costa, Sara Terezinha Olalla Saad and Fabiola Traina

    Citation: Applied Cancer Research 2017 37:25

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  20. Content type: Research article

    Polyamines present in human body are frequently considered as markers of occurrence of cancer. Therefore, the availability of simple and efficient method for determination of their level in body liquids and ti...

    Authors: Waldemar Balcerzak, Katarzyna Pokajewicz and Piotr P. Wieczorek

    Citation: Applied Cancer Research 2017 37:23

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  21. Content type: Research article

    Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive embryonal tumors of the central nervous system. They are largely characterized by inactivating mutations of the SMARCB1 tumor suppressor gene. AT/RT patien...

    Authors: Mario Suzuki, Kashyap Patel, Chiang-Ching Huang, Felipe D’Almeida Costa, Akihide Kondo, Fernando Augusto Soares, Tadanori Tomita and Simone Treiger Sredni

    Citation: Applied Cancer Research 2017 37:14

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  22. Content type: Research article

    Cancer cachexia is a debilitating paraneoplastic syndrome featuring unintended weight loss and skeletal muscle atrophy. Evidence suggests that bone health may also be compromised, further limiting mobility and...

    Authors: Andy V. Khamoui, Ming-Chia Yeh, Do-Houn Kim, Bong-Sup Park, Marcus L. Elam, Edward Jo, Bahram H. Arjmandi and Jeong-Su Kim

    Citation: Applied Cancer Research 2017 37:17

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