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  1. Research article

    Epigenetic signature of differentially methylated genes in cutaneous melanoma

    Cutaneous melanoma (CM) is the most aggressive subtype of skin cancer, with increasing incidence over the past several decades. DNA methylation is a key element of several biological processes such as genomic ...

    Dimitrius T. Pramio, André Y. Kashiwabara, Paula C. Pennacchi, Maria P. Rivas, Silvya S. Maria-Engler, Antônio H. J. F. M. Campos, João P. Duprat, Dirce M. Carraro and Ana C. V. Krepischi

    Applied Cancer Research 2017 37:34

    Published on: 12 October 2017

  2. Research article

    What questions are most important to pancreatic cancer patients soon after diagnosis? A multicenter survey

    Pancreatic cancer has a poor prognosis. Patients might be better able to cope with their disease when the information is discussed that they consider most important. We investigated what questions pancreatic p...

    Lisa J. M. Ronde-Schoone, Chulja J. Pek, Rutger-Jan Swijnenburg and Arwen H. Pieterse

    Applied Cancer Research 2017 37:32

    Published on: 18 September 2017

  3. Research article

    Cytotoxicity of Mycobacterium indicus pranii on Mia-Pa-Ca2 cells

    MIP is a cultivable, non-pathogenic organism, which shares several antigens with Mycobacterium tuberculosis and Mycobacterium leprae. It has several proposed clinical applications. However, its cytotoxic effect o...

    A. Darji, N. Desai, R. Modi, B. Khamar and S. Rajkumar

    Applied Cancer Research 2017 37:30

    Published on: 31 August 2017

  4. Review

    Clinical features and preventive therapies of radiation-induced xerostomia in head and neck cancer patient: a literature review

    Xerostomia or dry mouth is one of the most common and disturbing adverse effects following radiotherapy for head and neck cancer (HNC). This complication strongly increases the risk for dental caries, difficul...

    Graziella Chagas Jaguar, José Divaldo Prado, Daniel Campanhã and Fábio Abreu Alves

    Applied Cancer Research 2017 37:31

    Published on: 15 August 2017

  5. Research article

    Standard of care of patients with Chronic Myeloid Leukemia (CML) treated in community based oncology group practices between 2001-2015 in Rhineland-Palatinate (Germany)

    The aim of this study was to assess retrospectively treatment and outcome of CML-patients in community based oncology practices in Germany and whether European LeukemiaNET (ELN) recommendations were followed.

    Rudolf Weide, Bernhard Rendenbach, Monika Grundheber, Oswald Burkhard, Joachim Behringer, Michael Maasberg, Peter Ehscheidt, John W. Strehl, Richard Hansen and Stefan Feiten

    Applied Cancer Research 2017 37:26

    Published on: 11 July 2017

  6. Review

    Distant metastases in phyllodes tumours of the breast: an overview

    Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms, comprising 0.3 – 1.0% of all primary breast malignancies in Western countries, but accounting for a higher proportion of primary br...

    Valerie Cui Yun Koh, Aye Aye Thike and Puay Hoon Tan

    Applied Cancer Research 2017 37:15

    Published on: 7 July 2017

  7. Case report

    Circulating tumor cells as a new and additional approach to follow-up patients with serous low-grade ovarian adenocarcinoma – a case report and review of the literature

    Current methods for follow-up of Ovarian Cancer (OC) are widespread, especially with CA125, which, however, is not a perfect biomarker and thus further investigation for new methods of evaluation are warranted...

    Marcelo Corassa, Andrea Paiva Gadelha Guimarães, Solange Moraes Sanches, Marcello Ferretti Fanelli, Bruna Maria M. Rocha, Alexandre Andre Balieiro A. da Costa, Vanessa Alves, Glauco Baiocchi and Ludmilla T. Domingos Chinen

    Applied Cancer Research 2017 37:12

    Published on: 4 July 2017

  8. Research article

    Expression of the c-MET, HGF and VEGF biomarkers in intestinal and diffuse gastric cancer in the Brazilian population: a pilot study for the standardization of the quantitative PCR technique

    Gastric carcinoma (GC) is the third leading cause of death among malignant tumors worldwide, causing approximately 900,000 deaths/year. Changes in oncogenes that encode tyrosine kinase receptors play an import...

    Bianca Della Croce Vieira Cota, Karine Sampaio Lima, André Márcio Murad, Marcelo Antônio Pascoal Xavier, Mônica Maria Demas Álvares Cabral and Luiz Gonzaga Vaz Coelho

    Applied Cancer Research 2017 37:18

    Published on: 4 July 2017

  9. Research article

    Expression analysis of transglutaminase 2 in premalignant lesions of the cervix

    The medical management of low-grade squamous intraepithelial lesions (LSIL) is variable, thus a biomarker could assist with the clinical conduct. Type 2 transglutaminase (TG2) has been proposed as a cellular-i...

    Karen Olivia Bazzo Goulart, Alessandra Eifler Guerra Godoy, Isnard Elman Litvin and Fábio Firmbach Pasqualotto

    Applied Cancer Research 2017 37:27

    Published on: 3 July 2017

  10. Research article

    SIVA, a target of p53, is downregulated in myelodysplastic syndromes

    SIVA is a transcriptional target of p53 that plays a potential role in the development and progression of cancer. In this study, we analyzed SIVA1 and SIVA2 expression, and its associa...

    João Agostinho Machado-Neto, Paula de Melo Campos, Patricia Favaro, Mariana Lazarini, Renata Scopim-Ribeiro, Irene Lorand-Metze, Fernando Ferreira Costa, Sara Terezinha Olalla Saad and Fabiola Traina

    Applied Cancer Research 2017 37:25

    Published on: 15 June 2017

  11. Research article

    Loss of expression of the Neural Cell Adhesion Molecule 1 (NCAM1) in atypical teratoid/rhabdoid tumors: a new diagnostic marker?

    Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive embryonal tumors of the central nervous system. They are largely characterized by inactivating mutations of the SMARCB1 tumor suppressor gene. AT/RT patien...

    Mario Suzuki, Kashyap Patel, Chiang-Ching Huang, Felipe D’Almeida Costa, Akihide Kondo, Fernando Augusto Soares, Tadanori Tomita and Simone Treiger Sredni

    Applied Cancer Research 2017 37:14

    Published on: 9 June 2017

  12. Research article

    Bone mineral density and content are differentially impacted by aerobic and resistance training in the colon-26 mouse model of cancer cachexia

    Cancer cachexia is a debilitating paraneoplastic syndrome featuring unintended weight loss and skeletal muscle atrophy. Evidence suggests that bone health may also be compromised, further limiting mobility and...

    Andy V. Khamoui, Ming-Chia Yeh, Do-Houn Kim, Bong-Sup Park, Marcus L. Elam, Edward Jo, Bahram H. Arjmandi and Jeong-Su Kim

    Applied Cancer Research 2017 37:17

    Published on: 8 June 2017

  13. Research article

    Gastrointestinal stromal tumors treated at a Brazilian Cancer Center: evaluation of clinical, epidemiological, and therapeutic profiles

    Gastrointestinal stromal tumors (GISTs) originate as precursor cells of the interstitial cells of Cajal in the myenteric plexus and generally have a mutation in the tyrosine kinase receptor, C-KIT (CD117). The...

    Erinaldo Rocha Paes Landim, Carolina de Barros Jaqueta, Rubens Chojniak, Felipe José Fernandez Coimbra, Celso Abdon Lopes de Mello, Patricia Oriani, Almir Galvão Vieira Bitencourt and Luana de Paula Silva Paes

    Applied Cancer Research 2017 37:21

    Published on: 7 June 2017

  14. Research article

    Prevalence of human papillomavirus infection in squamous cell carcinoma of the anal canal in a Northeast City in Brazil: viral genotyping and clinical aspects

    Anal cancer malignancies comprise about 1.5 to 3% of cancers from the gastrointestinal in which high-risk types of human papillomavirus (HR-HPV) is responsible for >80% of cases. The aim of this work was to de...

    Sulayne Janayna Araujo Guimarães, Flávia Castello Branco Vidal, Jéssica Maran Cavalcante Soares, Maria do Desterro Soares Brandão Nascimento, Luísa Lina Villa and Luciane Maria Oliveira Brito

    Applied Cancer Research 2017 37:19

    Published on: 6 June 2017

  15. Research article

    Cancer detection ratio in a population participating in cancer screening programs at a tertiary care cancer center in São Paulo

    Tertiary care cancer centers can act as reference units for prevention and early detection programs. The purpose of this study was to describe the profile of the Cancer Prevention Campaign (CPC) participants a...

    Diego Fernandes dos Santos, Maria Paula Curado and Diego Rodrigues Mendonça e Silva

    Applied Cancer Research 2017 37:24

    Published on: 2 June 2017

  16. Review

    The genetic and epigenetic landscapes of hepatoblastomas

    Primary liver cancers are rare in children, and the most common type is hepatoblastoma (HB), an embryonal tumor with histological features that resemble different stages of liver cell differentiation. However,...

    Talita Ferreira Marques Aguiar, Thaise Nayane Carneiro, Cecilia Maria Lima da Costa, Carla Rosenberg, Isabela Werneck da Cunha and Ana Cristina Victorino Krepischi

    Applied Cancer Research 2017 37:20

    Published on: 23 May 2017

  17. Review

    Targeting the mitochondria in acute myeloid leukemia

    Acute myeloid leukemia (AML) is a clonal hematologic neoplasm characterized by heterogeneity of genetic abnormalities found at diagnosis. These abnormalities serve to classify patients by risk group into low, ...

    Silvia Elena Sánchez-Mendoza and Eduardo M. Rego

    Applied Cancer Research 2017 37:22

    Published on: 23 May 2017

  18. Research article

    Breast cancer diagnosed before the 40 years: imaging findings and correlation with histology and molecular subtype

    To evaluate the imaging findings in patients with breast cancer diagnosed before age 40 and their correlation with histological type and molecular subtype.

    Deise Santiago Girão Eugênio, Juliana Alves Souza, Rubens Chojniak, Almir Galvão Vieira Bitencourt, Luciana Graziano and Elvira Ferreira Marques

    Applied Cancer Research 2017 37:16

    Published on: 12 May 2017

  19. Review

    Current applications of molecular pathology in colorectal carcinoma

    Molecular pathology is playing an increasingly important role in the treatment and overall management of patients with colorectal carcinoma. Three distinct genetic pathways have been identified that play a rol...

    Raul S. Gonzalez, Kay Washington and Chanjuan Shi

    Applied Cancer Research 2017 37:13

    Published on: 11 May 2017

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