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  1. Content type: Research article

    Mutations in the RAS/RAF pathway predict resistance to anti-epidermal growth factor receptor antibodies in colorectal cancer (CRC), and may be targets for future therapies. This study investigates concordance of

    Authors: Nikki Knijn, Carlijn van de Water, Shannon van Vliet, Jos Meijer, Sietske Riemersma, Maria Tebar, Cornelis Punt, Leonie Mekenkamp, Femke Simmer and Iris Nagtegaal

    Citation: Applied Cancer Research 2019 39:9

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  2. Content type: Research article

    The capacity for prognostic prediction of cutaneous melanoma, one of the most aggressive cancers, is still difficult due to the tumor heterogeneity and lack of reliable tumor markers. The objective of this stu...

    Authors: Luciana El Halal Schuch, Munique Mendonça Azevedo, Roque Furian, Péttala Rigon, Keli Cristine Reiter, Isabel Crivelatti, Felice Riccardi and Claudia Giuliano Bica

    Citation: Applied Cancer Research 2019 39:10

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  3. Content type: Research article

    Human biological material has become an important resource for biomedical research. Tumor Biobanks are facilities that collect, store and distribute samples of tumor and normal tissue for further use in basic ...

    Authors: Fernanda C. S. Lupinacci, Elisa N. Ferreira, Martin Roffe, Hermano M. Bellato, Dirce M. Carraro and Glaucia N. M. Hajj

    Citation: Applied Cancer Research 2019 39:8

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  4. Content type: Research article

    Detection of somatic mutations is a mandatory practice for therapeutic definition in precision oncology. However, somatic mutation detection protocols use DNA from formalin-fixed and paraffin-embedded (FFPE) t...

    Authors: C. M. Berra, G. T. Torrezan, C. A. de Paula, R. Hsieh, S. V. Lourenço and D. M. Carraro

    Citation: Applied Cancer Research 2019 39:7

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  5. Content type: Research article

    The population-based mammography screening program (MSP) is aimed to reduce breast cancer mortality, to detect breast cancer at an early stage, and to allow for less invasive treatment. However, it also has so...

    Authors: Eva-Maria Berens, Simone Kaucher, Sandra van Eckert, Maren Reder, Petra Kolip and Jacob Spallek

    Citation: Applied Cancer Research 2019 39:6

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  6. Content type: Research article

    Squamous cell carcinoma (SCC) of head and neck is highly prevalent in South-asian countries, owing to high consumption of areca nut/gutka and chewing tobacco. p27kip1 is a tumor suppressor gene, thought to be dow...

    Authors: Atif Ali hashmi, Saher Aijaz, Muhammad Irfan, Zubaida Fida Hussain, Shumaila Kanwal Hashmi, Huda Asif and Naveen Faridi

    Citation: Applied Cancer Research 2019 39:5

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  7. Content type: Research article

    Colorectal cancer (CRC) is one of the most common cancers in Japan. Many factors influence this cancer, one of which is circadian rhythm disruption. Our research investigated the correlation between single-nuc...

    Authors: Holipah, Takuji Hinoura, Naomi Kozaka and Yoshiki Kuroda

    Citation: Applied Cancer Research 2019 39:3

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  8. Content type: Research article

    PTEN loss is observed in 20–30% of prostate cancers and is associated with a poor outcome, but clinical details of the impact of this biomarker are unclear for intermediate grade tumors.

    Authors: C. G. Picanço-Albuquerque, T. Vidotto, C. S. Pereira, F. P. Saggioro, T. Jamaspishvili, M. Koti, D. M. Berman, J. A. Squire and R. B. Reis

    Citation: Applied Cancer Research 2019 39:1

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  9. Content type: Research article

    Epidermal growth factor receptor (EGFR) is potential prognostic biomarker expressed in many human cancers. Prognostic significance of EGFR immunohistochemical expression has not been established in prostatic a...

    Authors: Atif Ali hashmi, Shumaila Kanwal Hashmi, Muhammad Irfan, Huda Asif, Laila Nisar, Maheen Naeem, Erum Yousuf Khan, Samina Baloch and Naveen Faridi

    Citation: Applied Cancer Research 2019 39:2

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  10. Content type: Review

    Brachytherapy as a form of treatment for gynecological tumors has been used for a long time in Brazil (since 1991) and can be considered as a form of radiotherapy treatment. High Dose Rate (HDR) brachytherapy ...

    Authors: Mari Uyeda, Fabian Friedrich and Antonio Cassio Assis Pellizzon

    Citation: Applied Cancer Research 2018 38:19

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  11. Content type: Regular article

    After undergoing liver transplantation, children are susceptible to oral lesions due to immunosuppressant drugs that are needed to maintain the transplant. In this context, it is important to understand how di...

    Authors: Agatha S. Rodrigues, Vinicius F. Calsavara, Felipe I. B. Silva, Fábio A. Alves and Ana P. M. Vivas

    Citation: Applied Cancer Research 2018 38:16

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  12. Content type: Research article

    Pain continues to be a prevalent yet undertreated problem among cancer patients. Achieving adequate control of cancer pain is influenced by physicians’ knowledge and practices, which have been found to be inad...

    Authors: Ahmad M. Samara, Haneen A. Toba and Sa’ed H. Zyoud

    Citation: Applied Cancer Research 2018 38:15

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  13. Content type: Research article

    Low English fluency in large culturally diverse institutions may contribute to meager minority accrual. Our objective was to: 1) Assess knowledge of proper consenting procedures among the research team when co...

    Authors: Jeanine N. Staples, Jenny Lester, Andrew Li, Christine Walsh, Ilana Cass, Beth Y. Karlan, Catherine Bresee and B. J. Rimel

    Citation: Applied Cancer Research 2018 38:14

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  14. Content type: Research article

    In 2017, there will be 107,000 cases of gynecologic cancer diagnosed in the US with an overall survival of around 70%-most occurring in post-menopausal individuals. In this study, we have examined a younger (≤...

    Authors: Lauren Pinckney, Justin Collins, Christine M. G. Schammel, Matt Gevaert, David P. Schammel, W. Jeffrey Edenfield, Jeffrey Elder and Larry E. Puls

    Citation: Applied Cancer Research 2018 38:13

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  15. Content type: Research article

    Malnutrition is common in patients with gastric and esophageal tumors, and is predominantly associated with loss of lean body mass. Adequate assessment of preoperative nutritional status is essential for progn...

    Authors: Thais Manfrinato Miola, Elizabeth Launeir Santos da Conceição, Juliana de Oliveira Souza, Paula Nicole Vieira Barbosa, Felipe José Fernandez Coimbra and Almir Galvão Vieira Bitencourt

    Citation: Applied Cancer Research 2018 38:12

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  16. Content type: Research article

    Tumour volume at therapy initiation, Vi, is rarely available in cancer patients, and the last pre-treatment tumour volume available is from previous diagnostic imaging (Vd). Therapeutic efficacy is thus evaluated...

    Authors: Esmaeil Mehrara and Eva Forssell-Aronsson

    Citation: Applied Cancer Research 2018 38:11

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  17. Content type: Case report

    Mycosis fungoides (MF), a T-cell lymphoma, is the most common variant of primary cutaneous lymphomas. The discrete clinical aspect of the early patch-stage and an overlapping clinical presentation with other e...

    Authors: Ana Carolina Porto, Tatiana Pinto Blumetti, Adriana Silveira Pessoa Mendes, João Pedreira Duprat Neto, Gisele Gargantini Rezze and Juliana Casagrande Tavoloni Braga

    Citation: Applied Cancer Research 2018 38:10

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  18. Content type: Research article

    Diffusion-weighted magnetic resonance imaging (DW-MRI) provides information on the cellularity and movement of water molecules in tissues and 18F–fluorodeoxyglucose (18F–FDG) positron emission tomography/compu...

    Authors: Chiang Jeng Tyng, Marcos Duarte Guimarães, Almir Galvão Vieira Bitencourt, Luiz Carlos Mattos dos Santos, Paula Nicole Vieira Pinto Barbosa, Charles Edouard Zurstrassen, Eduardo Nóbrega Pereira, Jefferson Luiz Gross and Rubens Chojniak

    Citation: Applied Cancer Research 2018 38:9

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  19. Content type: Research article

    Circulating tumor cells (CTCs) play an important role in progression and metastasis, particularly in form of cluster, which is called circulating tumor microemboli (CTM), and can be found in the peripheral blo...

    Authors: Mônica Taiane de Macêdo Diaz, Emne Ali Abdallah, Milena Shizue Tariki, Alexcia Camila Braun, Aldo Lourenço Abbade Dettino, Ulisses Ribaldo Nicolau, Vanessa da Silva Alves and Ludmilla Thomé Domingos Chinen

    Citation: Applied Cancer Research 2018 38:8

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  20. Content type: Research article

    Cyclin D1 is a protein essential for transition from G1 to S phase during cell cycle progression, which has an oncogenic potential and is highly expressed in several human malignancies. However, in view of the he...

    Authors: Jaqueline Cristina Fernandes, Ana Paula Nunes Rodrigues Alves, Juan Luiz Coelho-Silva, Renata Scopim-Ribeiro, Bruna Alves Fenerich, Belinda Pinto Simões, Eduardo Magalhães Rego, João Agostinho Machado-Neto and Fabiola Traina

    Citation: Applied Cancer Research 2018 38:7

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  21. Content type: Research article

    Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Brazil does not have an official well established program for screening colorectal cancer. The aim of this study was to compare Gu...

    Authors: Bruna Elisa Catin Kupper, Samuel Aguiar Junior, Wilson Toshihiko Nakagawa, Renata Mayumi Takahashi, Ranyell Matheus Spencer Sobreira Batista, Tiago Santoro Bezerra, Paulo Roberto Stevanato Filho, Thiago Celestino Chulam and Ademar Lopes

    Citation: Applied Cancer Research 2018 38:5

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  22. Content type: Research article

    Preoperative assessment of tumor size is important in breast cancer treatment planning, especially in breast conservation surgeries. The use of the Magnetic Resonance Imaging (MRI) is increasing among patients...

    Authors: Luciana Karla Lira França, Almir Galvão Vieira Bitencourt, Cynthia Aparecida Bueno de Toledo Osório, Luciana Graziano, Camila Souza Guatelli, Juliana Alves Souza and Elvira Ferreira Marques

    Citation: Applied Cancer Research 2018 38:2

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  23. Content type: Research article

    Data on renal replacement therapy (RRT) in cancer patients with acute kidney injury (AKI) in the intensive care unit (ICU) and how these factors influence the efficiency of dialysis and the outcomes of these p...

    Authors: Edwiges Ita de Miranda Moura, Germana Alves de Brito, Juliana Vendramini Cordeiro Fernandes, Lilian Guardian, Joubert Araujo Alves, Fabiana Plaza Sequeira, Marina Harume Imanishe and Benedito Jorge Pereira

    Citation: Applied Cancer Research 2018 38:3

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  24. Content type: Research article

    The creation and evolution of research nurse, connected with some specialty, brings a new path to be covered and structured inside nursering. The position of Researcher Nurse was initially created decentralize...

    Authors: Bruna Tirapelli, Silvana Soares dos Santos, Bruna Elisa Catin Kupper and Amanda Aparecida França de Nobrega

    Citation: Applied Cancer Research 2018 38:1

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  25. Content type: Review

    Follicular dendritic cell (FDC) tumor is an uncommon neoplasm. It generally presents as a slow-growing, painless mass, without systemic symptoms. Histological features usually include low grade spindle cell pr...

    Authors: Aline Caldart Tregnago, Diogo Lago Morbeck, Felipe D’Almeida Costa, Antonio Hugo José Froes M. Campos, Fernando Augusto Soares and José Vassallo

    Citation: Applied Cancer Research 2017 37:45

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  26. Content type: Research article

    Colorectal cancer (CRC) is a neoplasia with high incidence and mortality rates. It had been suggested that the inflammatory response is an important CRC prognostic factor. The disordered and accelerated prolif...

    Authors: Adriano Carneiro da Costa, Paulo Roberto Stevanato Filho, Samuel Aguiar Júnior, Fábio de Oliveira Ferreira, Maria Dirlei Begnami, Vladmir Cláudio Cordeiro de Lima, Fernando de Santa Cruz Oliveira, Wilson Toshihiko Nakagawa, Ranyell Matheus Spencer and Ademar Lopes

    Citation: Applied Cancer Research 2017 37:44

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  27. Content type: Research article

    It is expected that about 65,000 new patients will be diagnosed with head and neck cancer in 2017 in the United States. Patients with recurrent or advanced or metastatic head and neck do not have good survival...

    Authors: Rohit Bishnoi, Chintan Shah, Harini Bejjanki, Jeffery A. Bennett and David N. Reisman

    Citation: Applied Cancer Research 2017 37:43

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  28. Content type: Research article

    The development of oral cavity cancer is related to the accumulation of genetic alterations. The activation of AKT is associated with the proliferation and progression of many malignancies. It is thought that ...

    Authors: Darkle Modesto Ferreira, Tercia J. Neves, Luiz Guilherme C. A. Lima, Fabio A. Alves and Maria D. Begnami

    Citation: Applied Cancer Research 2017 37:41

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  29. Content type: Research article

    Functional speech rehabilitation after total laryngectomy remains one of the most challenging issues in head and neck multidisciplinary care. Tracheoesophageal puncture for voice prosthesis insertion performed...

    Authors: Adriane Graicer Pelosof, Alvaro Moura Seraphim, Claudia Zitron Sztokfisz, Jose Guilherme Vartanian and Luiz Paulo Kowalski

    Citation: Applied Cancer Research 2017 37:42

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  30. Content type: Research article

    Patients with stage II CRC have a varying survival outcome. Therefore, it is critical to identify prognostic biomarkers that can define more aggressive forms of the disease. We assessed the expression levels o...

    Authors: Abeer A. Bahnassy, Mohammad El-Sayed, Nasr M. Ali, Ola Khorshid, Marwa M. Hussein, Hend F. Yousef, Marwa A. Mohanad, Abdel-Rahman N. Zekri and Salem E. Salem

    Citation: Applied Cancer Research 2017 37:39

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  31. Content type: Research article

    Tet methylcytosine dioxygenase 2 (TET2) is frequently mutated and/or downregulated in myeloid neoplasm, including myelodysplastic syndromes. Despite the extensive studies, the specific contribution of TET2 in ...

    Authors: Renata Scopim-Ribeiro, João Agostinho Machado-Neto, Adriana da Silva Santos Duarte, Fernando Ferreira Costa, Sara Teresinha Olalla Saad and Fabiola Traina

    Citation: Applied Cancer Research 2017 37:38

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  32. Content type: Research article

    Alternative splicing commonly occurs in cancer cells and many cancer specific splice variants have been reported as potential candidate biomarkers of the disease. We have studied human tissue Kallikrein 7 (KLK...

    Authors: Samina Ejaz, Faiz-ul-Hassan Nasim, Muhammad Ashraf and Gulzar Ahmad

    Citation: Applied Cancer Research 2017 37:35

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  33. Content type: Research article

    Cutaneous melanoma (CM) is the most aggressive subtype of skin cancer, with increasing incidence over the past several decades. DNA methylation is a key element of several biological processes such as genomic ...

    Authors: Dimitrius T. Pramio, André Y. Kashiwabara, Paula C. Pennacchi, Maria P. Rivas, Silvya S. Maria-Engler, Antônio H. J. F. M. Campos, João P. Duprat, Dirce M. Carraro and Ana C. V. Krepischi

    Citation: Applied Cancer Research 2017 37:34

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  34. Content type: Research article

    Melanoma is a metastatic type of skin cancer that is difficult to treat and the majority of efforts are directed to the design of new drugs. Medicinal Plants have been the primary source of medicines since lif...

    Authors: Sonam Pandey

    Citation: Applied Cancer Research 2017 37:33

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  35. Content type: Research article

    Pancreatic cancer has a poor prognosis. Patients might be better able to cope with their disease when the information is discussed that they consider most important. We investigated what questions pancreatic p...

    Authors: Lisa J. M. Ronde-Schoone, Chulja J. Pek, Rutger-Jan Swijnenburg and Arwen H. Pieterse

    Citation: Applied Cancer Research 2017 37:32

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  36. Content type: Research article

    In recent decades neoadjuvant therapies such as combined chemotherapy and radiotherapy have been introduced for cancer management. Compared with monotherapy modalities, neoadjuvant therapy is associated with g...

    Authors: Ali Ebrahimi Fard, M. B. Tavakoli, Hossein Salehi and Hamid Emami

    Citation: Applied Cancer Research 2017 37:29

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  37. Content type: Research article

    MIP is a cultivable, non-pathogenic organism, which shares several antigens with Mycobacterium tuberculosis and Mycobacterium leprae. It has several proposed clinical applications. However, its cytotoxic effect o...

    Authors: A. Darji, N. Desai, R. Modi, B. Khamar and S. Rajkumar

    Citation: Applied Cancer Research 2017 37:30

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  38. Content type: Research article

    Current developments in the targeted therapies of non-small-cell lung carcinoma demand accurate classification to dodge the adverse drug response and to yield maximum therapeutic outcome. Accurate classificati...

    Authors: Sangeet Bhaumik, Firoz Ahmad and Bibhu Ranjan Das

    Citation: Applied Cancer Research 2017 37:28

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  39. Content type: Review

    Xerostomia or dry mouth is one of the most common and disturbing adverse effects following radiotherapy for head and neck cancer (HNC). This complication strongly increases the risk for dental caries, difficul...

    Authors: Graziella Chagas Jaguar, José Divaldo Prado, Daniel Campanhã and Fábio Abreu Alves

    Citation: Applied Cancer Research 2017 37:31

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  40. Content type: Research article

    The aim of this study was to assess retrospectively treatment and outcome of CML-patients in community based oncology practices in Germany and whether European LeukemiaNET (ELN) recommendations were followed.

    Authors: Rudolf Weide, Bernhard Rendenbach, Monika Grundheber, Oswald Burkhard, Joachim Behringer, Michael Maasberg, Peter Ehscheidt, John W. Strehl, Richard Hansen and Stefan Feiten

    Citation: Applied Cancer Research 2017 37:26

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  41. Content type: Review

    Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms, comprising 0.3 – 1.0% of all primary breast malignancies in Western countries, but accounting for a higher proportion of primary br...

    Authors: Valerie Cui Yun Koh, Aye Aye Thike and Puay Hoon Tan

    Citation: Applied Cancer Research 2017 37:15

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  42. Content type: Research article

    Gastric carcinoma (GC) is the third leading cause of death among malignant tumors worldwide, causing approximately 900,000 deaths/year. Changes in oncogenes that encode tyrosine kinase receptors play an import...

    Authors: Bianca Della Croce Vieira Cota, Karine Sampaio Lima, André Márcio Murad, Marcelo Antônio Pascoal Xavier, Mônica Maria Demas Álvares Cabral and Luiz Gonzaga Vaz Coelho

    Citation: Applied Cancer Research 2017 37:18

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  43. Content type: Case report

    Current methods for follow-up of Ovarian Cancer (OC) are widespread, especially with CA125, which, however, is not a perfect biomarker and thus further investigation for new methods of evaluation are warranted...

    Authors: Marcelo Corassa, Andrea Paiva Gadelha Guimarães, Solange Moraes Sanches, Marcello Ferretti Fanelli, Bruna Maria M. Rocha, Alexandre Andre Balieiro A. da Costa, Vanessa Alves, Glauco Baiocchi and Ludmilla T. Domingos Chinen

    Citation: Applied Cancer Research 2017 37:12

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