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  1. A large number of cancer patients relapse after chemotherapeutic treatment. The immune system is capable of identifying and destroying cancer cells, so recent studies have highlighted the growing importance of...

    Authors: Subhadip Pati, Anandi Chowdhury, Sumon Mukherjee, Aharna Guin, Shravanti Mukherjee and Gaurisankar Sa

    Citation: Applied Cancer Research 2020 40:7

    Content type: Review

    Published on:

  2. Ovarian cancer is the most common gynecological malignancy. In patients with advanced ovarian cancer, some biological parameters have prognostic implementations. P27kip1 is an inhibitor of a cycline-dependent kin...

    Authors: Amani A. Alrehaili, Majed AlMourgi, Amal F Gharib, Wael H Elsawy, Khadiga Ahmed Ismail, Howaida Mahmoud Hagag, Farah Anjum and Nermin Raafat

    Citation: Applied Cancer Research 2020 40:6

    Content type: Research article

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  3. Next-generation sequencing (NGS) based assay for finding an actionable driver in non-small-cell lung cancer is a less used modality in clinical practice. With a long list of actionable targets, limited tissue,...

    Authors: Anurag Mehta, Smreti Vasudevan, Sanjeev Kumar Sharma, Manoj Panigrahi, Moushumi Suryavanshi, Mumtaz Saifi and Ullas Batra

    Citation: Applied Cancer Research 2020 40:4

    Content type: Research article

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  4. Randomized controlled trials (RCTs) play an integral role in childhood cancer research. Several efforts to improve the quality of reporting of clinical trials have been published in recent years, including the...

    Authors: Samuel Jellison, Nicholas Hoffsommer, Alexander Hoelscher and Matt Vassar

    Citation: Applied Cancer Research 2020 40:5

    Content type: Research article

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  5. Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-hodgkin’s lymphoma. In oral cavity represents approximately 2% of all malignancies.

    Authors: Camila S. Oliveira, Matheus H. A. de Lima, Felipe D’Almeida Costa, Danyel Elias da Cruz Perez, Talita Maira Bueno da Silveira da Rocha and Fabio Abreu Alves

    Citation: Applied Cancer Research 2020 40:3

    Content type: Case report

    Published on:

  6. Cell culture (spheroid and 2D monolayer cultures) is an essential tool in drug discovery. Piperlongumine (PLN), a naturally occurring alkaloid present in the long pepper (Piper longum), has been implicated in the...

    Authors: Bruna Isabela Biazi, Thalita Alves Zanetti, Lilian Areal Marques, Adrivanio Baranoski, Giuliana Castello Coatti and Mário Sérgio Mantovani

    Citation: Applied Cancer Research 2020 40:2

    Content type: Research article

    Published on:

  7. Oral squamous cell carcinoma (OSCC) is the most frequently occurring malignant tumor of the head and neck region. Chk2 (Checkpoint kinase 2) is considered a tumor suppressor gene that acts on the cellular resp...

    Authors: Suziene Caroline Silva Cardoso, Andressa Duarte, Luciana Yamamoto de Almeida, Jorge Esquiche León and Alfredo Ribeiro-Silva

    Citation: Applied Cancer Research 2020 40:1

    Content type: Research article

    Published on:

  8. Oral submucous fibrosis (OSMF) is a potentially malignant disorder largely seen in the South-Asian countries where areca nut is found to be the main predisposing factor. Pentoxifylline, a methylxanthine deriva...

    Authors: Annette M. Bhambal, Ajay Bhambal, U. S. Shukla and Aashna Dhingra

    Citation: Applied Cancer Research 2019 39:15

    Content type: Research article

    Published on:

  9. Cancer survivors often lack the knowledge and skills to return to positive health behaviors following a cancer diagnosis. The use of retreats may be an ideal environment for cancer survivors to learn about hea...

    Authors: Iris Lesser, Erin McGowan and Lisa Belanger

    Citation: Applied Cancer Research 2019 39:14

    Content type: Letter to the editor

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  10. Some prospective studies have observed associations between periodontal disease and breast cancer. Therefore, the aim of the present study was to investigate the composition of the subgingival biofilm of women...

    Authors: Vivian Rodrigues Bernhard, Marcelo Faveri, Marciel Silva Santos, Maria da Conceição Machado Gomes, Roberta Grasseli Batitucci, Caio Junji Tanaka, Magda Feres and Alfredo Feitosa

    Citation: Applied Cancer Research 2019 39:13

    Content type: Research article

    Published on:

  11. Gastric cancer (GC) is the fifth most common type of cancer worldwide with high incidences in Asia, Central, and South American countries. This patchy distribution means that GC studies are neglected by large ...

    Authors: Thais F. Bartelli, Lais L. Senda de Abrantes, Helano C. Freitas, Andrew M. Thomas, Jordana M. Silva, Gabriela E. Albuquerque, Luiza F. Araújo, Gabriela P. Branco, Maria G. de Amorim, Marianna S. Serpa, Isabella K. T. M. Takenaka, Deborah T. Souza, Lucas O. Monção, Bruno S. Moda, Renan Valieris, Alexandre Defelicibus…

    Citation: Applied Cancer Research 2019 39:12

    Content type: Letter to the editor

    Published on:

  12. Delays that postpone the evaluation and management of malignancy may lead to considerable morbidity. The primary objective of this study was to assess the time required to diagnose and treat lung cancer at an ...

    Authors: Vishal Vashistha, Chandrashekhar Choudhari, Avneet Garg, Aditi Gupta, Gopanandan Parthasarathy, Deepali Jain, Karan Madan, Vijay Hadda, G. C. Khilnani, Randeep Guleria and Anant Mohan

    Citation: Applied Cancer Research 2019 39:11

    Content type: Research article

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  13. Mutations in the RAS/RAF pathway predict resistance to anti-epidermal growth factor receptor antibodies in colorectal cancer (CRC), and may be targets for future therapies. This study investigates concordance of

    Authors: Nikki Knijn, Carlijn van de Water, Shannon van Vliet, Jos Meijer, Sietske Riemersma, Maria Tebar, Cornelis Punt, Leonie Mekenkamp, Femke Simmer and Iris Nagtegaal

    Citation: Applied Cancer Research 2019 39:9

    Content type: Research article

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  14. The capacity for prognostic prediction of cutaneous melanoma, one of the most aggressive cancers, is still difficult due to the tumor heterogeneity and lack of reliable tumor markers. The objective of this stu...

    Authors: Luciana El Halal Schuch, Munique Mendonça Azevedo, Roque Furian, Péttala Rigon, Keli Cristine Reiter, Isabel Crivelatti, Felice Riccardi and Claudia Giuliano Bica

    Citation: Applied Cancer Research 2019 39:10

    Content type: Research article

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  15. Human biological material has become an important resource for biomedical research. Tumor Biobanks are facilities that collect, store and distribute samples of tumor and normal tissue for further use in basic ...

    Authors: Fernanda C. S. Lupinacci, Elisa N. Ferreira, Martin Roffe, Hermano M. Bellato, Dirce M. Carraro and Glaucia N. M. Hajj

    Citation: Applied Cancer Research 2019 39:8

    Content type: Research article

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  16. Detection of somatic mutations is a mandatory practice for therapeutic definition in precision oncology. However, somatic mutation detection protocols use DNA from formalin-fixed and paraffin-embedded (FFPE) t...

    Authors: C. M. Berra, G. T. Torrezan, C. A. de Paula, R. Hsieh, S. V. Lourenço and D. M. Carraro

    Citation: Applied Cancer Research 2019 39:7

    Content type: Research article

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  17. The population-based mammography screening program (MSP) is aimed to reduce breast cancer mortality, to detect breast cancer at an early stage, and to allow for less invasive treatment. However, it also has so...

    Authors: Eva-Maria Berens, Simone Kaucher, Sandra van Eckert, Maren Reder, Petra Kolip and Jacob Spallek

    Citation: Applied Cancer Research 2019 39:6

    Content type: Research article

    Published on:

  18. Squamous cell carcinoma (SCC) of head and neck is highly prevalent in South-asian countries, owing to high consumption of areca nut/gutka and chewing tobacco. p27kip1 is a tumor suppressor gene, thought to be dow...

    Authors: Atif Ali hashmi, Saher Aijaz, Muhammad Irfan, Zubaida Fida Hussain, Shumaila Kanwal Hashmi, Huda Asif and Naveen Faridi

    Citation: Applied Cancer Research 2019 39:5

    Content type: Research article

    Published on:

  19. Colorectal cancer (CRC) is one of the most common cancers in Japan. Many factors influence this cancer, one of which is circadian rhythm disruption. Our research investigated the correlation between single-nuc...

    Authors: Holipah, Takuji Hinoura, Naomi Kozaka and Yoshiki Kuroda

    Citation: Applied Cancer Research 2019 39:3

    Content type: Research article

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  20. PTEN loss is observed in 20–30% of prostate cancers and is associated with a poor outcome, but clinical details of the impact of this biomarker are unclear for intermediate grade tumors.

    Authors: C. G. Picanço-Albuquerque, T. Vidotto, C. S. Pereira, F. P. Saggioro, T. Jamaspishvili, M. Koti, D. M. Berman, J. A. Squire and R. B. Reis

    Citation: Applied Cancer Research 2019 39:1

    Content type: Research article

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  21. Epidermal growth factor receptor (EGFR) is potential prognostic biomarker expressed in many human cancers. Prognostic significance of EGFR immunohistochemical expression has not been established in prostatic a...

    Authors: Atif Ali hashmi, Shumaila Kanwal Hashmi, Muhammad Irfan, Huda Asif, Laila Nisar, Maheen Naeem, Erum Yousuf Khan, Samina Baloch and Naveen Faridi

    Citation: Applied Cancer Research 2019 39:2

    Content type: Research article

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  22. Brachytherapy as a form of treatment for gynecological tumors has been used for a long time in Brazil (since 1991) and can be considered as a form of radiotherapy treatment. High Dose Rate (HDR) brachytherapy ...

    Authors: Mari Uyeda, Fabian Friedrich and Antonio Cassio Assis Pellizzon

    Citation: Applied Cancer Research 2018 38:19

    Content type: Review

    Published on:

  23. After undergoing liver transplantation, children are susceptible to oral lesions due to immunosuppressant drugs that are needed to maintain the transplant. In this context, it is important to understand how di...

    Authors: Agatha S. Rodrigues, Vinicius F. Calsavara, Felipe I. B. Silva, Fábio A. Alves and Ana P. M. Vivas

    Citation: Applied Cancer Research 2018 38:16

    Content type: Regular article

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  24. Pain continues to be a prevalent yet undertreated problem among cancer patients. Achieving adequate control of cancer pain is influenced by physicians’ knowledge and practices, which have been found to be inad...

    Authors: Ahmad M. Samara, Haneen A. Toba and Sa’ed H. Zyoud

    Citation: Applied Cancer Research 2018 38:15

    Content type: Research article

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  25. Low English fluency in large culturally diverse institutions may contribute to meager minority accrual. Our objective was to: 1) Assess knowledge of proper consenting procedures among the research team when co...

    Authors: Jeanine N. Staples, Jenny Lester, Andrew Li, Christine Walsh, Ilana Cass, Beth Y. Karlan, Catherine Bresee and B. J. Rimel

    Citation: Applied Cancer Research 2018 38:14

    Content type: Research article

    Published on:

  26. In 2017, there will be 107,000 cases of gynecologic cancer diagnosed in the US with an overall survival of around 70%-most occurring in post-menopausal individuals. In this study, we have examined a younger (≤...

    Authors: Lauren Pinckney, Justin Collins, Christine M. G. Schammel, Matt Gevaert, David P. Schammel, W. Jeffrey Edenfield, Jeffrey Elder and Larry E. Puls

    Citation: Applied Cancer Research 2018 38:13

    Content type: Research article

    Published on:

  27. Malnutrition is common in patients with gastric and esophageal tumors, and is predominantly associated with loss of lean body mass. Adequate assessment of preoperative nutritional status is essential for progn...

    Authors: Thais Manfrinato Miola, Elizabeth Launeir Santos da Conceição, Juliana de Oliveira Souza, Paula Nicole Vieira Barbosa, Felipe José Fernandez Coimbra and Almir Galvão Vieira Bitencourt

    Citation: Applied Cancer Research 2018 38:12

    Content type: Research article

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  28. Tumour volume at therapy initiation, Vi, is rarely available in cancer patients, and the last pre-treatment tumour volume available is from previous diagnostic imaging (Vd). Therapeutic efficacy is thus evaluated...

    Authors: Esmaeil Mehrara and Eva Forssell-Aronsson

    Citation: Applied Cancer Research 2018 38:11

    Content type: Research article

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  29. Mycosis fungoides (MF), a T-cell lymphoma, is the most common variant of primary cutaneous lymphomas. The discrete clinical aspect of the early patch-stage and an overlapping clinical presentation with other e...

    Authors: Ana Carolina Porto, Tatiana Pinto Blumetti, Adriana Silveira Pessoa Mendes, João Pedreira Duprat Neto, Gisele Gargantini Rezze and Juliana Casagrande Tavoloni Braga

    Citation: Applied Cancer Research 2018 38:10

    Content type: Case report

    Published on:

  30. Diffusion-weighted magnetic resonance imaging (DW-MRI) provides information on the cellularity and movement of water molecules in tissues and 18F–fluorodeoxyglucose (18F–FDG) positron emission tomography/compu...

    Authors: Chiang Jeng Tyng, Marcos Duarte Guimarães, Almir Galvão Vieira Bitencourt, Luiz Carlos Mattos dos Santos, Paula Nicole Vieira Pinto Barbosa, Charles Edouard Zurstrassen, Eduardo Nóbrega Pereira, Jefferson Luiz Gross and Rubens Chojniak

    Citation: Applied Cancer Research 2018 38:9

    Content type: Research article

    Published on:

  31. Circulating tumor cells (CTCs) play an important role in progression and metastasis, particularly in form of cluster, which is called circulating tumor microemboli (CTM), and can be found in the peripheral blo...

    Authors: Mônica Taiane de Macêdo Diaz, Emne Ali Abdallah, Milena Shizue Tariki, Alexcia Camila Braun, Aldo Lourenço Abbade Dettino, Ulisses Ribaldo Nicolau, Vanessa da Silva Alves and Ludmilla Thomé Domingos Chinen

    Citation: Applied Cancer Research 2018 38:8

    Content type: Research article

    Published on:

  32. Cyclin D1 is a protein essential for transition from G1 to S phase during cell cycle progression, which has an oncogenic potential and is highly expressed in several human malignancies. However, in view of the he...

    Authors: Jaqueline Cristina Fernandes, Ana Paula Nunes Rodrigues Alves, Juan Luiz Coelho-Silva, Renata Scopim-Ribeiro, Bruna Alves Fenerich, Belinda Pinto Simões, Eduardo Magalhães Rego, João Agostinho Machado-Neto and Fabiola Traina

    Citation: Applied Cancer Research 2018 38:7

    Content type: Research article

    Published on:

  33. Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Brazil does not have an official well established program for screening colorectal cancer. The aim of this study was to compare Gu...

    Authors: Bruna Elisa Catin Kupper, Samuel Aguiar Junior, Wilson Toshihiko Nakagawa, Renata Mayumi Takahashi, Ranyell Matheus Spencer Sobreira Batista, Tiago Santoro Bezerra, Paulo Roberto Stevanato Filho, Thiago Celestino Chulam and Ademar Lopes

    Citation: Applied Cancer Research 2018 38:5

    Content type: Research article

    Published on:

  34. Preoperative assessment of tumor size is important in breast cancer treatment planning, especially in breast conservation surgeries. The use of the Magnetic Resonance Imaging (MRI) is increasing among patients...

    Authors: Luciana Karla Lira França, Almir Galvão Vieira Bitencourt, Cynthia Aparecida Bueno de Toledo Osório, Luciana Graziano, Camila Souza Guatelli, Juliana Alves Souza and Elvira Ferreira Marques

    Citation: Applied Cancer Research 2018 38:2

    Content type: Research article

    Published on:

  35. Data on renal replacement therapy (RRT) in cancer patients with acute kidney injury (AKI) in the intensive care unit (ICU) and how these factors influence the efficiency of dialysis and the outcomes of these p...

    Authors: Edwiges Ita de Miranda Moura, Germana Alves de Brito, Juliana Vendramini Cordeiro Fernandes, Lilian Guardian, Joubert Araujo Alves, Fabiana Plaza Sequeira, Marina Harume Imanishe and Benedito Jorge Pereira

    Citation: Applied Cancer Research 2018 38:3

    Content type: Research article

    Published on:

  36. The creation and evolution of research nurse, connected with some specialty, brings a new path to be covered and structured inside nursering. The position of Researcher Nurse was initially created decentralize...

    Authors: Bruna Tirapelli, Silvana Soares dos Santos, Bruna Elisa Catin Kupper and Amanda Aparecida França de Nobrega

    Citation: Applied Cancer Research 2018 38:1

    Content type: Research article

    Published on:

  37. Follicular dendritic cell (FDC) tumor is an uncommon neoplasm. It generally presents as a slow-growing, painless mass, without systemic symptoms. Histological features usually include low grade spindle cell pr...

    Authors: Aline Caldart Tregnago, Diogo Lago Morbeck, Felipe D’Almeida Costa, Antonio Hugo José Froes M. Campos, Fernando Augusto Soares and José Vassallo

    Citation: Applied Cancer Research 2017 37:45

    Content type: Review

    Published on:

  38. Colorectal cancer (CRC) is a neoplasia with high incidence and mortality rates. It had been suggested that the inflammatory response is an important CRC prognostic factor. The disordered and accelerated prolif...

    Authors: Adriano Carneiro da Costa, Paulo Roberto Stevanato Filho, Samuel Aguiar Júnior, Fábio de Oliveira Ferreira, Maria Dirlei Begnami, Vladmir Cláudio Cordeiro de Lima, Fernando de Santa Cruz Oliveira, Wilson Toshihiko Nakagawa, Ranyell Matheus Spencer and Ademar Lopes

    Citation: Applied Cancer Research 2017 37:44

    Content type: Research article

    Published on:

  39. It is expected that about 65,000 new patients will be diagnosed with head and neck cancer in 2017 in the United States. Patients with recurrent or advanced or metastatic head and neck do not have good survival...

    Authors: Rohit Bishnoi, Chintan Shah, Harini Bejjanki, Jeffery A. Bennett and David N. Reisman

    Citation: Applied Cancer Research 2017 37:43

    Content type: Research article

    Published on:

  40. The development of oral cavity cancer is related to the accumulation of genetic alterations. The activation of AKT is associated with the proliferation and progression of many malignancies. It is thought that ...

    Authors: Darkle Modesto Ferreira, Tercia J. Neves, Luiz Guilherme C. A. Lima, Fabio A. Alves and Maria D. Begnami

    Citation: Applied Cancer Research 2017 37:41

    Content type: Research article

    Published on:

  41. Functional speech rehabilitation after total laryngectomy remains one of the most challenging issues in head and neck multidisciplinary care. Tracheoesophageal puncture for voice prosthesis insertion performed...

    Authors: Adriane Graicer Pelosof, Alvaro Moura Seraphim, Claudia Zitron Sztokfisz, Jose Guilherme Vartanian and Luiz Paulo Kowalski

    Citation: Applied Cancer Research 2017 37:42

    Content type: Research article

    Published on:

  42. Patients with stage II CRC have a varying survival outcome. Therefore, it is critical to identify prognostic biomarkers that can define more aggressive forms of the disease. We assessed the expression levels o...

    Authors: Abeer A. Bahnassy, Mohammad El-Sayed, Nasr M. Ali, Ola Khorshid, Marwa M. Hussein, Hend F. Yousef, Marwa A. Mohanad, Abdel-Rahman N. Zekri and Salem E. Salem

    Citation: Applied Cancer Research 2017 37:39

    Content type: Research article

    Published on:

  43. Tet methylcytosine dioxygenase 2 (TET2) is frequently mutated and/or downregulated in myeloid neoplasm, including myelodysplastic syndromes. Despite the extensive studies, the specific contribution of TET2 in ...

    Authors: Renata Scopim-Ribeiro, João Agostinho Machado-Neto, Adriana da Silva Santos Duarte, Fernando Ferreira Costa, Sara Teresinha Olalla Saad and Fabiola Traina

    Citation: Applied Cancer Research 2017 37:38

    Content type: Research article

    Published on:

  44. Alternative splicing commonly occurs in cancer cells and many cancer specific splice variants have been reported as potential candidate biomarkers of the disease. We have studied human tissue Kallikrein 7 (KLK...

    Authors: Samina Ejaz, Faiz-ul-Hassan Nasim, Muhammad Ashraf and Gulzar Ahmad

    Citation: Applied Cancer Research 2017 37:35

    Content type: Research article

    Published on:

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