Dighiero G, Hamblin TJ. Chronic lymphocytic leukaemia. Lancet. 2008;371(9617):1017–29.
Article
CAS
PubMed
Google Scholar
Khoshnaw N, Mohammed HA, Abdullah DA. Patterns of cancer in Kurdistan - results of eight years cancer registration in sulaymaniyah province-Kurdistan-Iraq. Asian Pac J Cancer Prev. 2015;16(18):8525–31.
Article
PubMed
Google Scholar
Altekruse SF, Kosary CL, Krapcho M, Neyman N, Aminou R, Waldron W, et al. SEER Cancer Statistics Review, 1975–2007. National Cancer Institute. 2010. Available from: http://seer.cancer.gov/csr/1975_2007/index.html. Accessed 7 Mar 2016.
Autret A, Martin SJ. Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis. Mol Cell. 2009;36(3):355–63.
Article
CAS
PubMed
Google Scholar
Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer. 2002;2(9):647–56.
Article
CAS
PubMed
Google Scholar
Llambi F, Moldoveanu T, Tait SWG, Bouchier-Hayes L, Temirov J, McCormick LL, et al. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell. 2011;44(4):517–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science. 2001;292(5517):727–30.
Article
CAS
PubMed
PubMed Central
Google Scholar
Strasser A, Cory S, Adams JM. Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases. EMBO J. 2011;30(18):3667–83.
Article
CAS
PubMed
PubMed Central
Google Scholar
García-Sáez AJ. The secrets of the Bcl-2 family. Cell Death Differ. 2012;19(11):1733–40.
Article
PubMed
PubMed Central
Google Scholar
Pedersen IM, Buhl AM, Klausen P, Geisler CH, Jurlander J. The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein–kinase–dependent mechanism. Blood. 2002;99(4):1314–9.
Article
CAS
PubMed
Google Scholar
Wang M, Han XH, Zhang L, Yang J, Qian JF, Shi YK, et al. Bortezomib is synergistic with rituximab and cyclophosphamide in inducing apoptosis of mantle cell lymphoma cells in vitro and in vivo. Leukemia. 2008;22(1):179–85.
Article
CAS
PubMed
Google Scholar
Herman SEM, Gordon AL, Wagner AJ, Heerema NA, Zhao W, Flynn JM, et al. Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116(12):2078–88.
Article
CAS
PubMed
PubMed Central
Google Scholar
Herman SEM, Gordon AL, Hertlein E, Ramanunni A, Zhang X, Jaglowski S, et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood. 2011;117(23):6287–96.
Article
CAS
PubMed
PubMed Central
Google Scholar
Platia J, Bucura O, Khosravi-Far R. Apoptotic cell signaling in cancer progression and therapy. Integr Biol. 2011;3(4):279–96.
Article
Google Scholar
Tse C, Shoemaker AR, Adickes J, Anderson MG, Chen J, Jin S, et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 2008;68(9):3421–8.
Article
CAS
PubMed
Google Scholar
Tahir SK, Yang X, Anderson MG, Morgan-Lappe SE, Sarthy AV, Chen J, et al. Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737. Cancer Res. 2007;67(3):1176–83.
Article
CAS
PubMed
Google Scholar
Reed JC. Bcl-2-family proteins and hematologic malignancies: history and future prospects. Blood. 2008;111(7):3322–30.
Article
CAS
PubMed
PubMed Central
Google Scholar
Stolz C, Hess G, Hähnel PS, Grabellus F, Hoffarth S, Schmid KW, et al. Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis. Blood. 2008;112(8):3312–21.
Article
CAS
PubMed
Google Scholar
Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A. 2005;102(39):13944–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Advani RH, Buggy JJ, Sharman JP, Smith SM, Boyd TE, Grant B, et al. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. J Clin Oncol. 2013;31(1):88–94.
Article
CAS
PubMed
Google Scholar
Roberts AW, Davids MS, Pagel JM, Kahl BS, Puvvada SD, Gerecitano JF, et al. Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia. N Engl J Med. 2016;374(4):311–22.
Article
CAS
PubMed
Google Scholar
Haupt S, Berger M, Goldberg Z, Haupt Y. Apoptosis - the p53 network. J Cell Sci. 2003;116(Pt 20):4077–85.
Article
CAS
PubMed
Google Scholar
Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature. 2000;408(6810):307–10.
Article
CAS
PubMed
Google Scholar
Klobušická M, Kusenda J, Babušíková O. Immunocytochemical detection of bcl-2 and p53 proteins in B-chronic lymphocytic leukemia patients. Neoplasma. 2002;49(6):387–93.
PubMed
Google Scholar
Lazaridou A, Miraxtsi C, Korantzis J, Eleftheriadis N, Christakis JI. Simultaneous detection of BCL-2 protein, trisomy 12, retinoblastoma and P53 monoallelic gene deletions in B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization (FISH): relation to disease status. Leuk Lymphoma. 2000;36(5–6):503–12.
Article
CAS
PubMed
Google Scholar
Prospects for p53-based cancer therapy. [cited 2016 Apr 12]. Available from: http://www.actabp.pl/pdf/2_2005/321.pdf.
Klobusická M, Kusenda J, Babusíková O. Immunocytochemical detection of bcl-2 and p53 proteins in B-chronic lymphocytic leukemia patients. Neoplasma. 2002;49(6):387–93.
PubMed
Google Scholar
Morrison WH, Hoppe RT, Weiss LM, Picozzi VJ, Horning SJ. Small lymphocytic lymphoma. J Clin Oncol. 1989;7(5):598–606.
Article
CAS
PubMed
Google Scholar
Santos FPS, O’Brien S. Small lymphocytic lymphoma and chronic lymphocytic leukemia: are they the same disease? Cancer J. 2013;18(5):396–403.
Reed JC. Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies. Semin Hematol. 1997;34(4 Suppl 5):9–19.
CAS
PubMed
Google Scholar
Aguilar-Santelises M, Rottenberg ME, Lewin N, Mellstedt H, Jondal M. Bcl-2,Bax andp53 expression in B-CLL in relation toin vitro survival and clinical progression. Int J Cancer [Internet]. Wiley Subscription Services, Inc., A Wiley Company; 1996;69(2):114–9.
Pepper C, Thomas A, Hoy T, Bentley P. Chlorambucil resistance in B-cell chronic lymphocytic leukaemia is mediated through failed Bax induction and selection of high Bcl-2-expressing subclones. Br J Haematol. 1997;104(3):581–8.
Article
Google Scholar
Begleiter A, Verburg L, Ashique A, Lee K, Israels LG, Mowat MR, et al. Comparison of antitumor activities of 2-chlorodeoxyadenosine and 9-beta-arabinosyl-2-fluoroadenine in chronic lymphocytic leukemia and marrow cells in vitro. Leukemia. 1995;9(11):1875–81.
CAS
PubMed
Google Scholar
Hillmen P, Skotnicki AB, Robak T, Jaksic B, Dmoszynska A, Wu J, et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol. 2007;25(35):5616–23.
Article
CAS
PubMed
Google Scholar
Plosker GL, Figgitt DP. Rituximab. Drugs. 2003;63(8):803–43. Springer International Publishing.
Article
CAS
PubMed
Google Scholar
Alas S, Emmanouilides C, Bonavida B. Inhibition of interleukin ten by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin’s lymphoma to apoptosis. Clin Cancer Res. 2001;7(3):709–23.
CAS
PubMed
Google Scholar
Cordone I, Masi S, Mauro FR, Soddu S, Morsilli O, Valentini T, et al. p53 Expression in B-Cell Chronic Lymphocytic Leukemia: A Marker of Disease Progression and Poor Prognosis. Blood. 1998;91(11):4342-9.
Thomas A, Pepper C, Hoy T, Bentley P. Bcl-2 and bax expression and chlorambucil-induced apoptosis in the T-cells and leukaemic B-cells of untreated B-cell chronic lymphocytic leukaemia patients. Leuk Res. 2000;24(10):813–21.
Article
CAS
PubMed
Google Scholar
Robertson LE, Plunkett W, McConnell K, Keating MJ, McDonnell TJ. Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. Leukemia. 1996;10(3):456–9.
CAS
PubMed
Google Scholar